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Alfredo Ramirez

Researcher at University of Cologne

Publications -  181
Citations -  16094

Alfredo Ramirez is an academic researcher from University of Cologne. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 43, co-authored 137 publications receiving 13075 citations. Previous affiliations of Alfredo Ramirez include University of Lübeck & University Hospital Bonn.

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Jean-Charles Lambert, +215 more
- 01 Dec 2013 - 
TL;DR: In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
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Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

Valentina Escott-Price, +194 more
- 12 Jun 2014 - 
TL;DR: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimers disease.
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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase.

Alfredo Ramirez, +16 more
- 10 Sep 2006 - 
TL;DR: Loss-of-function mutations in a previously uncharacterized, predominantly neuronal P-type ATPase gene, ATP13A2, underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia are described.
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Rebecca Sims, +487 more
- 01 Sep 2017 - 
TL;DR: Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease.
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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.

Gernot Kleinberger, +35 more
- 02 Jul 2014 - 
TL;DR: It is reported that missense mutations associated with FTD and FTD-like syndrome reduce TREM2 maturation, abolish shedding by ADAM proteases, and impair the phagocytic activity of TREM1-expressing cells.