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Luca Kleineidam
Researcher at German Center for Neurodegenerative Diseases
Publications - 65
Citations - 1675
Luca Kleineidam is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Medicine & Dementia. The author has an hindex of 13, co-authored 34 publications receiving 855 citations. Previous affiliations of Luca Kleineidam include University of Cologne & University Hospital Bonn.
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Journal ArticleDOI
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Gail Davies,Max Lam,Sarah E. Harris,Joey W. Trampush,Michelle Luciano,W. David Hill,Saskia P. Hagenaars,Saskia P. Hagenaars,Stuart J. Ritchie,Riccardo E. Marioni,Chloe Fawns-Ritchie,David C. Liewald,Judith A. Okely,Ari Ahola-Olli,Catriona L. K. Barnes,Lars Bertram,Joshua C. Bis,Katherine E. Burdick,Katherine E. Burdick,Katherine E. Burdick,Andrea Christoforou,Pamela DeRosse,Srdjan Djurovic,Srdjan Djurovic,Thomas Espeseth,Stella G. Giakoumaki,Sudheer Giddaluru,Daniel E. Gustavson,Caroline Hayward,Edith Hofer,M. Arfan Ikram,Robert Karlsson,Emma Knowles,Jari Lahti,Markus Leber,Shuo Li,Karen A. Mather,Ingrid Melle,Ingrid Melle,Derek W. Morris,Christopher Oldmeadow,Teemu Palviainen,Antony Payton,Raha Pazoki,Katja Petrovic,Chandra A. Reynolds,Muralidharan Sargurupremraj,Markus Scholz,Jennifer A. Smith,Albert V. Smith,Natalie Terzikhan,Natalie Terzikhan,Anbupalam Thalamuthu,Stella Trompet,Sven J. van der Lee,Erin B. Ware,Beverly Gwen Windham,Margaret J. Wright,Jingyun Yang,Jin Yu,David Ames,David Ames,Najaf Amin,Philippe Amouyel,Ole A. Andreassen,Nicola J. Armstrong,Amelia A. Assareh,John Attia,Deborah K. Attix,Dimitrios Avramopoulos,David A. Bennett,Anne C. Böhmer,Patricia A. Boyle,Henry Brodaty,Harry Campbell,Tyrone D. Cannon,Elizabeth T. Cirulli,Eliza Congdon,Emily Drabant Conley,Janie Corley,Simon R. Cox,Anders M. Dale,Abbas Dehghan,Danielle M. Dick,Dwight Dickinson,Johan G. Eriksson,Johan G. Eriksson,Evangelos Evangelou,Evangelos Evangelou,Jessica D. Faul,Ian Ford,Nelson A. Freimer,He Gao,Ina Giegling,Nathan A. Gillespie,Scott D. Gordon,R. F. Gottesman,Michael Griswold,Vilmundur Gudnason,Tamara B. Harris,Annette M. Hartmann,Alex Hatzimanolis,Alex Hatzimanolis,Gerardo Heiss,Elizabeth G. Holliday,Peter K. Joshi,Mika Kähönen,Sharon L.R. Kardia,Ida K. Karlsson,Luca Kleineidam,Luca Kleineidam,Luca Kleineidam,David S. Knopman,Nicole A. Kochan,Bettina Konte,John B.J. Kwok,John B.J. Kwok,Stephanie Le Hellard,Teresa Lee,Terho Lehtimäki,Shu-Chen Li,Shu-Chen Li,Tian Liu,Marisa Koini,Edythe D. London,Will Longstreth,Oscar L. Lopez,Anu Loukola,Tobias Luck,Astri J. Lundervold,Anders Lundquist,Leo-Pekka Lyytikäinen,Nicholas G. Martin,Grant W. Montgomery,Grant W. Montgomery,Alison D. Murray,Alison D. Murray,Anna C. Need,Raymond Noordam,Lars Nyberg,William Ollier,Goran Papenberg,Goran Papenberg,Alison Pattie,Ozren Polasek,Russell A. Poldrack,Bruce M. Psaty,Bruce M. Psaty,Simone Reppermund,Steffi G. Riedel-Heller,Richard J. Rose,Jerome I. Rotter,Panos Roussos,Panos Roussos,Suvi P. Rovio,Yasaman Saba,Fred W. Sabb,Perminder S. Sachdev,Claudia L. Satizabal,Claudia L. Satizabal,Matthias Schmid,Rodney J. Scott,Matthew A. Scult,Jeannette Simino,P. Eline Slagboom,Nikolaos Smyrnis,Nikolaos Smyrnis,Aicha Soumare,Nikos C. Stefanis,Nikos C. Stefanis,David J. Stott,Richard E. Straub,Kjetil Sundet,Adele M. Taylor,Kent D. Taylor,Ioanna Tzoulaki,Ioanna Tzoulaki,Christophe Tzourio,Christophe Tzourio,André G. Uitterlinden,Veronique Vitart,Aristotle N. Voineskos,Jaakko Kaprio,Jaakko Kaprio,Michael Wagner,Michael Wagner,Holger Wagner,Leonie Weinhold,K. Hoyan Wen,Elisabeth Widen,Qiong Yang,Wei Zhao,Hieab H.H. Adams,Dan E. Arking,Robert M. Bilder,Panos Bitsios,Eric Boerwinkle,Eric Boerwinkle,Ornit Chiba-Falek,Aiden Corvin,Philip L. De Jager,Philip L. De Jager,Stéphanie Debette,Stéphanie Debette,Gary Donohoe,Paul Elliott,Annette L. Fitzpatrick,Michael Gill,David C. Glahn,Sara Hägg,Narelle K. Hansell,Ahmad R. Hariri,M. Kamran Ikram,J. Wouter Jukema,Eero Vuoksimaa,Matthew C. Keller,William S. Kremen,Lenore J. Launer,Ulman Lindenberger,Aarno Palotie,Aarno Palotie,Nancy L. Pedersen,Neil Pendleton,David J. Porteous,Katri Räikkönen,Olli T. Raitakari,Alfredo Ramirez,Alfredo Ramirez,Ivar Reinvang,Igor Rudan,Dan Rujescu,Reinhold Schmidt,Helena Schmidt,Peter W. Schofield,Peter R. Schofield,Peter R. Schofield,John M. Starr,Vidar M. Steen,Julian N. Trollor,Steven T. Turner,Cornelia M. van Duijn,Arno Villringer,Arno Villringer,Daniel R. Weinberger,David R. Weir,James F. Wilson,Anil K. Malhotra,Anil K. Malhotra,Andrew M. McIntosh,Catharine R. Gale,Sudha Seshadri,Sudha Seshadri,Sudha Seshadri,Thomas H. Mosley,Jan Bressler,Todd Lencz,Todd Lencz,Ian J. Deary +257 more
TL;DR: In this paper, the authors combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci associated with general cognitive function.
Journal ArticleDOI
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez,Fahri Küçükali,Iris E. Jansen,Luca Kleineidam,Sonia Moreno-Grau,Najaf Amin,Adam C. Naj,R. Campos-Martín,Benjamin Grenier-Boley,Víctor Andrade,Peter Holmans,Anne Boland,Vincent Damotte,S. J. van der Lee,Marcos R. Costa,Teemu Kuulasmaa,Qiong Yang,Itziar de Rojas,Joshua C. Bis,Amber Yaqub,Ivana Prokic,Julien Chapuis,Shahzad Ahmad,Vilmantas Giedraitis,Dag Aarsland,Carla Abdelnour,Emilio Alarcón-Martín,Daniel Alcolea,Montserrat Alegret,Ignacio Alvarez,Victoria Alvarez,Nicola J. Armstrong,Anthoula Tsolaki,Carmen Antúnez,Ildebrando Appollonio,Marina Arcaro,Silvana Archetti,Alfonso Arias Pastor,Beatrice Arosio,Lavinia Athanasiu,Henri Bailly,Nerisa Banaj,Miquel Baquero,Sandra Barral,Alexa S. Beiser,Ana Pastor,Jennifer E. Below,Penny Benchek,Luisa Benussi,Claudine Berr,Céline Besse,Valentina Bessi,Giuliano Binetti,Alessandra Bizarro,Rafael Blesa,Mercè Boada,Eric Boerwinkle,S. Borroni,Silvia Boschi,Paola Bossù,Geir Bråthen,Jan Bressler,Catherine Bresner,Henry Brodaty,Keeley J. Brookes,Luis I. Brusco,Dolores Buiza-Rueda,Katharina Bürger,Vanessa Burholt,William S. Bush,Miguel Calero,Laura B. Cantwell,Geneviève Chêne,Jaeyoon Chung,Michael L. Cuccaro,Angel Carracedo,Roberta Cecchetti,Laura Cervera-Carles,Camille Charbonnier,Hung-Hsin Chen,Caterina Chillotti,Simona Ciccone,Jurgen A.H.R. Claassen,Christopher M. Clark,Elisa Conti,Anaïs Corma-Gómez,Emanuele Maria Costantini,Carlo Custodero,D. Daian,Maria Carolina Dalmasso,Antonio Daniele,Efthimios Dardiotis,Jean-François Dartigues,Peter Paul De Deyn,Katia de Paiva Lopes,Lot de Witte,Stéphanie Debette,Jürgen Deckert,Teodoro Del Ser,Nicola Denning,Anita L. DeStefano,Martin Dichgans,Janine Diehl-Schmid,Monica Diez-Fairen,Paolo Rosso,Srdjan Djurovic,Emmanuelle Duron,Emrah Düzel,Carole Dufouil,Gudny Eiriksdottir,Sebastiaan Engelborghs,Valentina Escott-Price,Ana Espinosa,Michael Ewers,Kelley Faber,Tagliavini Fabrizio,Sune F. Nielsen,David W. Fardo,Lucia Farotti,Chiara Fenoglio,Marta Fernández-Fuertes,Raffaele Ferrari,Catarina Beatriz Silva Ferreira,Evelyn Ferri,Bertrand Fin,Peter Fischer,Tormod Fladby,Klaus Fliessbach,Bernard Fongang,Myriam Fornage,Juan Fortea,Tatiana Foroud,Silvia Fostinelli,Nick C. Fox,Emilio Franco-Macías,María J. Bullido,Ana Frank-García,Lutz Froelich,Brian Fulton-Howard,Daniela Galimberti,José María García-Alberca,Pablo Garcia-Gonzalez,Sebastián García-Madrona,Guillermo García-Ribas,Roberta Ghidoni,Ina Giegling,Giaccone Giorgio,Alison Goate,Oliver Goldhardt,Duber Gomez-Fonseca,Antonio González-Pérez,Caroline Graff,Giulia Grande,Emma Green,Timo Grimmer,Edna Grünblatt,Michelle Grunin,Vilmundur Gudnason,Tamar Guetta-Baranes,Annakaisa Haapasalo,Georgios M. Hadjigeorgiou,Jonathan L. Haines,Kara L. Hamilton-Nelson,Harald Hampel,Olivier Hanon,John Hardy,T. Hartmann,Lucrezia Hausner,Janet C Harwood,Stefanie Heilmann-Heimbach,Seppo Helisalmi,Michael T. Heneka,Isabel Hernández,Martin J. Herrmann,Per Hoffmann,Clive Holmes,Henne Holstege,Raquel Huerto Vilas,Marc Hulsman,Jack Humphrey,Geert Jan Biessels,Xueqiu Jian,Charlotte Johansson,Gyungah Jun,Y. Kastumata,John S. K. Kauwe,Patrick G. Kehoe,Lena Kilander,Anne Kinhult Ståhlbom,Miia Kivipelto,Anne M. Koivisto,Johannes Kornhuber,Mary H. Kosmidis,Walter A. Kukull,Pavel P. Kuksa,Brian W. Kunkle,Amanda B. Kuzma,Carmen Lage,Erika J. Laukka,Lenore J. Launer,Alessandra Lauria,Chien‐Yueh Lee,Jenni Lehtisalo,Ondrej Lerch,Alberto Lleó,W. T. Longstreth,Oscar L. Lopez,Adolfo López de Munain,Seth Love,Malin Löwemark,L. Luckcuck,Kathryn L. Lunetta,Yiyi Ma,Juan Macías,Catherine A. MacLeod,Wolfgang Mader,Francesca Mangialasche,Marco Spallazzi,Marta Marquié,Rachel Marshall,Eden R. Martin,Angel Martin Montes,Carmen Martinez Rodriguez,Carlo Masullo,Richard Mayeux,Simon Head,Patrizia Mecocci,Miguel Medina,Alun Meggy,Shima Mehrabian,Silvia Mendoza,Manuel Menéndez-González,Pablo Mir,Susanne Moebus,Merel O. Mol,Laura Molina-Porcel,Laura Montrreal,Laura Morelli,Fermin Moreno,Kevin Morgan,Thomas H. Mosley,Markus M. Nöthen,Carolina Muchnik,Shubhabrata Mukherjee,Benedetta Nacmias,Tiia Ngandu,Gaël Nicolas,Børge G. Nordestgaard,Robert Olaso,Adelina Orellana,Michela Orsini,G. Ortega,Alessandro Padovani,Caffarra Paolo,Goran Papenberg,Lucilla Parnetti,Florence Pasquier,Pau Pastor,Gina M. Peloso,Alba Pérez-Cordón,Jordi Pérez-Tur,Pierre Pericard,Oliver Peters,Yolande A.L. Pijnenburg,Juan A. Pineda,Gerard Piñol-Ripoll,Claudia Pisanu,Thomas Polak,Julius Popp,Danielle Posthuma,Josef Priller,Raquel Delgado Puerta,Olivier Quenez,Inés Quintela,Jesper Qvist Thomassen,Alberto Rábano,Innocenzo Rainero,Farid Rajabli,Inez H.G.B. Ramakers,Luis Miguel Real,Marcel J. T. Reinders,Christiane Reitz,Dolly Reyes-Dumeyer,Perry G. Ridge,Steffi G. Riedel-Heller,Peter Riederer,Natalia Roberto,Eloy Rodríguez-Rodríguez,Arvid Rongve,I. Allende,Maitée Rosende-Roca,Jose Luis Royo,Elisa Rubino,Dan Rujescu,María Eugenia Sáez,Paraskevi Sakka,Ingvild Saltvedt,Angela Sanabria,M B Sánchez-Arjona,Florentino Sanchez-Garcia,Pascual Sanchez Juan,Raquel Sánchez-Valle,Sigrid Botne Sando,Chloé Sarnowski,Claudia L. Satizabal,Michela Scamosci,Nikolaos Scarmeas,Elio Scarpini,Philip Scheltens,Norbert Scherbaum,Martin Scherer,Matthias Schmid,Anja Schneider,Jonathan M. Schott,Geir Selbæk,Davide Seripa,Manuel Serrano,Jin Sha,Alexey A. Shadrin,Olivia Anna Skrobot,Susan Slifer,G. Snijders,Hilkka Soininen,Vincenzo Solfrizzi,Alina Solomon,Yeunjoo E. Song,Sandro Sorbi,Oscar Sotolongo-Grau,Gianfranco Spalletta,Annika Spottke,Alessio Squassina,Eystein Stordal,Juan Pablo Tartan,Lluís Tárraga,Niccolò Tesi,Anbupalam Thalamuthu,Tegos Thomas,Giuseppe Tosto,Latchezar Traykov,Lucio Tremolizzo,Anne Tybjærg-Hansen,André G. Uitterlinden,Abbe Ullgren,Ingun Ulstein,Sergi Valero,Otto Valladares,Christine Van Broeckhoven,Jeffery M. Vance,Badri N. Vardarajan,Aad Van Der Lugt,Jasper Van Dongen,Jeroen van Rooij,John C. van Swieten,Rik Vandenberghe,Frans R.J. Verhey,Jean-Sébastien Vidal,Jonathan Vogelgsang,Martin Vyhnalek,Michael Wagner,David Wallon,Li-San Wang,Ruiqi Wang,Leonie Weinhold,Jens Wiltfang,Gill Windle,Bob Woods,Mary Yannakoulia,Habil Zare,Yi Zhao,Xiaoling Zhang,Congcong Zhu,Miren Zulaica,Lindsay A. Farrer,Bruce M. Psaty,Mohsen Ghanbari,Towfique Raj,Perminder S. Sachdev,Karen A. Mather,Frank Jessen,M. Arfan Ikram,Alexandre de Mendonça,Jakub Hort,Magda Tsolaki,Margaret A. Pericak-Vance,Philippe Amouyel,Julie Williams,Ruth Frikke-Schmidt,Jordi Clarimón,Jean-François Deleuze,Giacomina Rossi,Sudha Seshadri,Ole A. Andreassen,Martin Ingelsson,Mikko Hiltunen,Kristel Sleegers,Gerard D. Schellenberg,Cornelia M. van Duijn,Rebecca Sims,Wiesje M. van der Flier,Agustín Ruiz,Alfredo Ramirez,Jean-Charles Lambert +401 more
TL;DR: This paper performed a two-stage genome-wide association study with 111,326 clinically diagnosed/proxy AD cases and 677,663 controls and found 75 risk loci, of which 42 were new at the time of analysis.
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Gail Davies,Max Lam,Sarah E. Harris,Joey W. Trampush,Michelle Luciano,W. David Hill,Saskia P. Hagenaars,Stuart J. Ritchie,Riccardo E. Marioni,Chloe Fawns-Ritchie,David C. Liewald,Judith A. Okely,Ari Ahola-Olli,Catriona L. K. Barnes,Lars Bertram,Joshua C. Bis,Katherine E. Burdick,Andrea Christoforou,Pamela DeRosse,Srdjan Djurovic,Thomas Espeseth,Stella G. Giakoumaki,Sudheer Giddaluru,Daniel E. Gustavson,Caroline Hayward,Edith Hofer,M. Arfan Ikram,Robert Karlsson,Emma Knowles,Jari Lahti,Markus Leber,Shuo Li,Karen A. Mather,Ingrid Melle,Derek W. Morris,Christopher Oldmeadow,Teemu Palviainen,Antony Payton,Raha Pazoki,K. Petrovic,Chandra A. Reynolds,Muralidharan Sargurupremraj,Markus Scholz,Jennifer A. Smith,Albert V. Smith,Natalie Terzikhan,Anbupalam Thalamuthu,Stella Trompet,Sven J. van der Lee,Erin B. Ware,B. Gwen Windham,Margaret J. Wright,Jingyun Yang,Jin Yu,David Ames,Najaf Amin,Philippe Amouyel,Ole A. Andreassen,Nicola J. Armstrong,Amelia A. Assareh,John Attia,Deborah K. Attix,Dimitrios Avramopoulos,David A. Bennett,Anne C. Boehmer,Patricia A. Boyle,Henry Brodaty,Harry Campbell,Tyrone D. Cannon,Elizabeth T. Cirulli,Eliza Congdon,Emily Drabant Conley,Janie Corley,Simon R. Cox,Anders M. Dale,Abbas Dehghan,Danielle M. Dick,Dwight Dickinson,Johan G. Eriksson,Evangelos Evangelou,Jessica D. Faul,Ian Ford,Nelson A. Freimer,He Gao,Ina Giegling,Nathan A. Gillespie,Scott D. Gordon,Rebecca F. Gottesman,Michael Griswold,Vilmundur Gudnason,Tamara B. Harris,Annette M. Hartmann,Alex Hatzimanolis,Gerardo Heiss,Elizabeth G. Holliday,Peter K. Joshi,Mika Kähönen,Sharon L.R. Kardia,Ida K. Karlsson,Luca Kleineidam,David S. Knopman,Nicole A. Kochan,Bettina Konte,John B.J. Kwok,Stephanie Le Hellard,Teresa Lee,Terho Lehtimäki,Shu-Chen Li,Tian Liu,Marisa Koini,Edythe D. London,Will Longstreth,Oscar L. Lopez,Anu Loukola,Tobias Luck,Astri J. Lundervold,Anders Lundquist,Leo-Pekka Lyytikäinen,Nicholas G. Martin,Grant W. Montgomery,Alison D. Murray,Anna C. Need,Raymond Noordam,Lars Nyberg,William E R Ollier,Goran Papenberg,Alison Pattie,Ozren Polasek,Russell A. Poldrack,Bruce M. Psaty,Simone Reppermund,Steffi G. Riedel-Heller,Richard J. Rose,Jerome I. Rotter,Panos Roussos,Suvi P. Rovio,Yasaman Saba,Fred W. Sabb,Perminder S. Sachdev,Claudia L. Satizabal,Matthias Schmid,Rodney J. Scott,Matthew A. Scult,Jeannette Simino,P. Eline Slagboom,Nikolaos Smyrnis,Aicha Soumare,Nikos C. Stefanis,David J. Stott,Richard E. Straub,Kjetil Sundet,Adele M. Taylor,Kent D. Taylor,Ioanna Tzoulaki,Christophe Tzourio,André G. Uitterlinden,Veronique Vitart,Aristotle N. Voineskos,Jaakko Kaprio,Michael Wagner,Holger Wagner,Leonie Weinhold,K. Hoyan Wen,Elisabeth Widen,Qiong Yang,Wei Zhao,Hieab H.H. Adams,Dan E. Arking,Robert M. Bilder,Panos Bitsios,Eric Boerwinkle,Ornit Chiba-Falek,Aiden Corvin,Philip L. De Jager,Stéphanie Debette,Gary Donohoe,Paul Elliott,Annette L. Fitzpatrick,Michael Gill,David C. Glahn,Sara Hägg,Narelle K. Hansell,Ahmad R. Hariri,M. Kamran Ikram,J. Wouter Jukema,Eero Vuoksimaa,Matthew C. Keller,William S. Kremen,Lenore J. Launer,Ulman Lindenberger,Aarno Palotie,Nancy L. Pedersen,Neil Pendleton,David J. Porteous,Katri Räikkönen,Olli T. Raitakari,Alfredo Ramirez,Ivar Reinvang,Igor Rudan,Dan Rujescu,Reinhold Schmidt,Helena Schmidt,Peter W. Schofield,Peter R. Schofield,John M. Starr,Vidar M. Steen,Julian N. Trollor,Steven T. Turner,Cornelia M. van Duijn,Arno Villringer,Daniel R. Weinberger,David R. Weir,James F. Wilson,Anil K. Malhotra,Andrew M. McIntosh,Catharine R. Gale,Sudha Seshadri,Thomas H. Mosley,Jan Bressler,Todd Lencz,Ian J. Deary +220 more
Journal ArticleDOI
Cerebrospinal Fluid Biomarkers and Clinical Progression in Patients with Subjective Cognitive Decline and Mild Cognitive Impairment.
Steffen Wolfsgruber,Steffen Wolfsgruber,Alexandra Polcher,Alexandra Polcher,Alexander Koppara,Alexander Koppara,Luca Kleineidam,Luca Kleineidam,Lutz Frölich,Oliver Peters,Michael Hüll,Eckart Rüther,Jens Wiltfang,Wolfgang Maier,Wolfgang Maier,Johannes Kornhuber,Piotr Lewczuk,Piotr Lewczuk,Frank Jessen,Frank Jessen,Michael Wagner,Michael Wagner +21 more
TL;DR: High prevalence of biomarker abnormality and clinical progression, together with the predictive value of CSF biomarkers, in memory clinic patients with SCD support the validity and usefulness of this condition as a "pre-MCI" at risk stage of AD.
Journal ArticleDOI
Differential Risk of Incident Alzheimer's Disease Dementia in Stable Versus Unstable Patterns of Subjective Cognitive Decline.
Steffen Wolfsgruber,Steffen Wolfsgruber,Luca Kleineidam,Luca Kleineidam,Michael Wagner,Michael Wagner,Edelgard Mösch,Horst Bickel,Dagmar Lϋhmann,Annette Ernst,Birgitt Wiese,Susanne Steinmann,Hans-Helmut König,Christian Brettschneider,Tobias Luck,Janine Stein,Siegfried Weyerer,Jochen Werle,Michael Pentzek,Angela Fuchs,Wolfgang Maier,Wolfgang Maier,Martin Scherer,Steffi G. Riedel-Heller,Frank Jessen,Frank Jessen +25 more
TL;DR: Findings suggest that longitudinal stability versus instability is an important modifying factor of the association between SCD and AD dementia risk.