Lutz Frölich

TL;DR: A two-stage genome-wide association study of Alzheimer's disease involving over 16,000 individuals, the most powerful AD GWAS to date, produced compelling evidence for association with Alzheimer's Disease in the combined dataset.

TL;DR: Meta-analyses of all data provided compelling evidence that ABCA7 and the MS4A gene cluster are new Alzheimer's disease susceptibility loci and independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance.

TL;DR: A new diagnostic indicator of FDG PET scan abnormality, based on age-adjusted t statistics and an automated voxel-based procedure, is presented and validated in a large data set comprising 110 normal controls and 395 patients with probable Alzheimer's disease (AD) that were studied in eight participating centers as discussed by the authors.

TL;DR: It is shown for the first time that insulin and c-peptide concentration in the brain are correlated and decrease with aging, as do brain insulin receptor densities, which favor the hypothesis that insulin dependent functions may be of pathogenetic relevance in sporadic Alzheimer's disease.

TL;DR: Independent evidence from two large studies demonstrates that these processes related to cholesterol metabolism and the innate immune response are aetiologically relevant, and suggests that they may be suitable targets for novel and existing therapeutic approaches.