L
Lynne Hartley
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 32
Citations - 7103
Lynne Hartley is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 26, co-authored 32 publications receiving 6824 citations. Previous affiliations of Lynne Hartley include Cooperative Research Centre.
Papers
More filters
Journal ArticleDOI
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.
Ian Lyons,Linda M. Parsons,Lynne Hartley,Ruili Li,Jane E. Andrews,Lorraine Robb,Richard P. Harvey +6 more
TL;DR: The data demonstrate that Nkx2-5 is essential for normal heart morphogenesis, myogenesis, and function, and this gene is a component of a genetic pathway required for myogenic specialization of the ventricles.
Journal ArticleDOI
Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
TL;DR: The expression data implicate Nkx-2.5 in commitment to and/or differentiation of the myocardial lineage and demonstrate that cardiogenic progenitors can be distinguished at a molecular level by late gastrulation.
Journal ArticleDOI
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
Marie Liesse Asselin-Labat,Kate D. Sutherland,Kate D. Sutherland,Holly E. Barker,Holly E. Barker,Richard M. Thomas,Mark Shackleton,Mark Shackleton,Mark Shackleton,Natasha C. Forrest,Lynne Hartley,Lorraine Robb,Frank Grosveld,Jacqueline van der Wees,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Jane E. Visvader +16 more
TL;DR: It is demonstrated that Gata-3 deficiency leads to an expansion of luminal progenitors and a concomitant block in differentiation, and introduced into a stem cell-enriched population induced maturation along the alveolar luminal lineage.
Journal ArticleDOI
Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.
L. Robb,Ian Lyons,Ruili Li,Lynne Hartley,Frank Köntgen,Richard P. Harvey,D. Metcalf,C G Begley +7 more
TL;DR: The results implicate scl as a crucial regulator of early hematopoiesis and Transcripts of GATA-1 and PU.1 transcription factors were absent from RNA from scl-/- yolk sacs and embryos.
Journal ArticleDOI
Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation
Lorraine Robb,Ruili Li,Lynne Hartley,Harshal Hanumant Nandurkar,Harshal Hanumant Nandurkar,Frank Koentgen,C G Begley +6 more
TL;DR: It is shown that female mice with a null mutation of the interleukin-11 receptor alpha chain are infertile because of defective decidualization, revealing a previously unrecognized critical role for IL-11 signaling in female reproduction.