L
Lynne V. Mayne
Researcher at University of Sussex
Publications - 23
Citations - 1811
Lynne V. Mayne is an academic researcher from University of Sussex. The author has contributed to research in topics: Xeroderma pigmentosum & Nucleotide excision repair. The author has an hindex of 17, co-authored 23 publications receiving 1761 citations.
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Journal ArticleDOI
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH
Karla A. Henning,Lei Li,Narayan V. Iyer,Lisa D. McDaniel,Michael S. Reagan,Randy J. Legerski,Roger A. Schultz,Miria Stefanini,Alan R. Lehmann,Lynne V. Mayne,Errol C. Friedberg +10 more
TL;DR: The cloned CSB gene encodes a member of a protein family that includes the yeast Snf2 protein, a component of the transcriptional regulator Swi/Snf, which can encode a WD repeat protein.
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Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum
Lynne V. Mayne,Alan R. Lehmann +1 more
TL;DR: It is shown that Cockayne cells, as well as cells from a number of patients with xeroderma pigmentosum, are sensitive to the lethal effects of UV irradiation in stationary phase under conditions in which no DNA is synthesized after irradiation.
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Comparative human cellular radiosensitivity: I. The effect of SV40 transformation and immortalisation on the gamma-irradiation survival of skin derived fibroblasts from normal individuals and from ataxia-telangiectasia patients and heterozygotes.
TL;DR: The greater sensitivity of A-T derived cells to gamma radiation is confirmed, and cells transformed by plasmids expressing SV40 T-antigen, both pre- and post-crisis, show this increased resistance, indicating that it is expression of SV 40 T- Antigen, rather than immortalization per se which is responsible for the change.
Journal Article
Abnormal Kinetics of DNA Synthesis in Ultraviolet Light-irradiated Cells from Patients with Cockayne's Syndrome
TL;DR: The recovery of DNA synthesis in normal cells appears to be unaffected by fluorodeoxyuridine but inhibited by cycloheximide, which suggests a possible requirement for de novo protein synthesis.
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Efficient immortalization and morphological transformation of human fibroblasts by transfection with SV40 DNA linked to a dominant marker
TL;DR: It is suggested that the use of a dominant selectable marker linked to the SV40 early region increases the probability of establishing an immortal human cell line.