L
Lyudmila V. Borovikova
Publications - 6
Citations - 7264
Lyudmila V. Borovikova is an academic researcher. The author has contributed to research in topics: Tumor necrosis factor alpha & Vagus nerve. The author has an hindex of 6, co-authored 6 publications receiving 6787 citations.
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Journal ArticleDOI
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Lyudmila V. Borovikova,Svetlana Ivanova,Minghuang Zhang,Huan Yang,Galina I. Botchkina,Linda R. Watkins,Haichao Wang,Naji N. Abumrad,John W. Eaton,Kevin J. Tracey +9 more
TL;DR: Direct electrical stimulation of the peripheral vagus nerve in vivo during lethal endotoxaemia in rats inhibited TNF synthesis in liver, attenuated peak serum TNF amounts, and prevented the development of shock.
Journal ArticleDOI
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Haichao Wang,Ona Bloom,Minghuang Zhang,Jaideep M. Vishnubhakat,Michael Ombrellino,Jiantu Che,Asia Frazier,Huan Yang,Svetlana Ivanova,Lyudmila V. Borovikova,Kirk R. Manogue,Eugen Faist,Edward Abraham,Jan Andersson,Ulf Andersson,Patricia E. Molina,Naji N. Abumrad,Andrew E. Sama,Kevin J. Tracey +18 more
TL;DR: High mobility group-1 (HMG-1) protein was found to be released by cultured macrophages more than 8 hours after stimulation with endotoxin, TNF, or IL-1, and showed increased serum levels after endotoxin exposure, suggesting that this protein warrants investigation as a therapeutic target.
Journal ArticleDOI
Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation.
Lyudmila V. Borovikova,Svetlana Ivanova,Dominic Nardi,Minghuang Zhang,Huan Yang,Michael Ombrellino,Kevin J. Tracey +6 more
TL;DR: In this paper, the role of the central nervous system (CNS) and efferent vagus nerve signaling in CNI-1493-mediated modulation of acute inflammation in the periphery was identified.
Journal ArticleDOI
Spermine inhibition of monocyte activation and inflammation.
TL;DR: Ex vivo administration of BAP in vivo significantly augmented the development of carrageenan-induced paw edema and nitric oxide release, indicating that endogenous spermine normally inhibits the innate inflammatory response by restraining macrophages.
Role of vagus nerve signaling in CNI-1493-mediated suppression of acute
Lyudmila V. Borovikova,Svetlana Ivanova,Dominic Nardi,Minghuang Zhang,Huan Yang,Michael Ombrellino,Kevin J. Tracey +6 more
TL;DR: The results now identify a previously unrecognized role of efferent vagus nerve activity in mediating the central action of an anti-inflammatory agent.