M. Cristina Errico

TL;DR: In vitro and in vivo functional studies, including the use of antisense "antagomir" oligonucleotides, confirmed the key role of miR-221/-222 in regulating the progression of human melanoma; this suggests that targeted therapies suppressing miR -221/222 may prove beneficial in advanced melanoma.

TL;DR: In this article, the authors showed that miR-126 and miR126* play a tumor suppressor role in human melanoma through direct or indirect repression of several key oncogenic molecules.

TL;DR: The inhibition of miRNA-221 and -222, which are abnormally expressed in melanoma and favor the induction of the malignant phenotype by downregulating c-KIT receptor and p27Kip, might in the future represent an efficient treatment for translation into the clinical setting.

TL;DR: It is shown that the HOXB7/PBX2 dimer acts as a positive transcriptional regulator of the oncogenic microRNA‐221 and ‐222, demonstrating c‐FOS as a direct target of miR‐221&222 and confirming the HXR9 efficacy in the treatment of human melanoma malignancy, whilst sparing normal human melanocytes.

TL;DR: It is demonstrated that the proto‐oncogene ETS‐1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR‐222 by direct binding to its promoter region.