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Federica Felicetti
Researcher at Istituto Superiore di Sanità
Publications - 30
Citations - 3294
Federica Felicetti is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Melanoma & Regulation of gene expression. The author has an hindex of 18, co-authored 30 publications receiving 3023 citations.
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Journal ArticleDOI
MicroRNA-133 controls cardiac hypertrophy
Alessandra Carè,Daniele Catalucci,Federica Felicetti,Désirée Bonci,Antonio Addario,Paolo Gallo,Marie Louise Bang,Patrizia Segnalini,Yusu Gu,Nancy D. Dalton,Leonardo Elia,Michael V.G. Latronico,Morten A. Høydal,Camillo Autore,Matteo Antonio Russo,Gerald W. Dorn,Øyvind Ellingsen,Pilar Ruiz-Lozano,Kirk L. Peterson,Carlo M. Croce,Cesare Peschle,Gianluigi Condorelli +21 more
TL;DR: The data show thatmiR-133, and possibly miR-1, are key regulators of cardiac hypertrophy, suggesting their therapeutic application in heart disease.
Journal ArticleDOI
The Promyelocytic Leukemia Zinc Finger–MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms
Federica Felicetti,M. Cristina Errico,Lisabianca Bottero,Patrizia Segnalini,Antonella Stoppacciaro,Mauro Biffoni,Nadia Felli,Gianfranco Mattia,Marina Petrini,Mario P. Colombo,Cesare Peschle,Alessandra Carè +11 more
TL;DR: In vitro and in vivo functional studies, including the use of antisense "antagomir" oligonucleotides, confirmed the key role of miR-221/-222 in regulating the progression of human melanoma; this suggests that targeted therapies suppressing miR -221/222 may prove beneficial in advanced melanoma.
Journal ArticleDOI
Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma
Federica Felicetti,Alessandra De Feo,Carolina Coscia,Rossella Puglisi,Francesca Pedini,Luca Pasquini,Maria Bellenghi,Maria Cristina Errico,Elena Pagani,Alessandra Carè +9 more
TL;DR: Data supported the role of miR-222 in melanoma tumorigenesis, supported its responsibility in the exosome-associated melanoma properties, thus further indicating this miR as potential diagnostic and prognostic biomarker and its abrogation as a future therapeutic option.
Journal Article
HOXB7: A Key Factor for Tumor-associated Angiogenic Switch
Alessandra Carè,Federica Felicetti,Ettore Meccia,Lisabianca Bottero,Mariella Parenza,Antonella Stoppacciaro,Cesare Peschle,Mario P. Colombo +7 more
TL;DR: HXB7 gene or protein is a target to aim at to inhibit tumor-associated neoangiogenesis, considering the number and the redundancy of proangiogenic molecules that should be targeted one by one to theoretically achieve the same effect.
Journal ArticleDOI
Caveolin-1 tumor-promoting role in human melanoma
Federica Felicetti,Isabella Parolini,Lisabianca Bottero,Katia Fecchi,Maria Cristina Errico,Carla Raggi,Mauro Biffoni,Francesca Spadaro,Michael P. Lisanti,Massimo Sargiacomo,Alessandra Carè +10 more
TL;DR: A secreted fraction of Cav‐1 associated with cell released microvesicular particles able to stimulate in vitro anchorage independence, migration and invasion in a paracrine/autocrine fashion and, more important, competent to convey metastatic asset from the donor melanoma to the less aggressive recipient cell line.