M
M. de Haas
Researcher at Leiden University Medical Center
Publications - 102
Citations - 5717
M. de Haas is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Medicine & Antibody. The author has an hindex of 38, co-authored 80 publications receiving 5383 citations. Previous affiliations of M. de Haas include University of Amsterdam.
Papers
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Journal ArticleDOI
FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype
TL;DR: Differences in IgG binding among the three Fc gammaRIIIa-48L/R/H isoforms are a consequence of the linked, biallelic Fc Gamma receptor IIIa-158V/F polymorphism at amino-acid position 158.
Journal ArticleDOI
Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro
Christa H. E. Homburg,M. de Haas,A. E. G. K. Von Dem Borne,Arthur J. Verhoeven,Chris P. M. Reutelingsperger,Dirk Roos +5 more
TL;DR: The results indicate that soluble Fc gamma RIII in body fluids might be derived for a large part from neutrophils undergoing apoptosis in the tissues.
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Nomenclature of human platelet antigens.
Paul Metcalfe,Nicholas A. Watkins,Willem H. Ouwehand,Willem H. Ouwehand,Cécile Kaplan,Peter J. Newman,Riitta Kekomäki,M. de Haas,Richard H. Aster,Y. Shibata,J. Smith,Volker Kiefel,Sentot Santoso +12 more
Journal Article
Role of neutrophil Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16) polymorphic forms in phagocytosis of human IgG1- and IgG3-opsonized bacteria and erythrocytes.
Robbert G. M. Bredius,C. A. P. Fijen,M. de Haas,Ed J. Kuijper,R. S. Weening,J. G. J. Van De Winkel,Theo A. Out +6 more
TL;DR: A critical role of Fc gamma R allotypes in functional interactions with biologically relevant IgG subclass antibodies is illustrated and it is shown that IgG3 anti-D sensitized erythrocytes formed more rosettes and were phagocytosed at a higher rate with PMN carrying Fc Gamma RIIa-H131 than with PMn carrying IIa-R131.
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Neutrophil Fc gamma RIIIb deficiency, nature, and clinical consequences: a study of 21 individuals from 14 families.
TL;DR: Genotyping showed a normal Fc gamma RIIa phenotype distribution among the F c gamma RIIIb-negative individuals, thus excluding the possibility that the presence of the favorable IgG2-binding low-responder isoform of Fc Gamma RIIA (131-H) contributed to the overall absence of recurrent bacterial infections.