M
Maâmar Souidi
Researcher at Institut de radioprotection et de sûreté nucléaire
Publications - 74
Citations - 1333
Maâmar Souidi is an academic researcher from Institut de radioprotection et de sûreté nucléaire. The author has contributed to research in topics: Population & Thyroid. The author has an hindex of 21, co-authored 70 publications receiving 1194 citations.
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Journal ArticleDOI
Statin Induction of Liver Fatty Acid-Binding Protein (L-FABP) Gene Expression Is Peroxisome Proliferator-activated Receptor-α-dependent
Jean-François Landrier,Charles Thomas,Jacques Grober,Hélène Duez,Frédéric Percevault,Maâmar Souidi,Christine Linard,Bart Staels,Philippe Besnard +8 more
TL;DR: Data demonstrate that L-FABP expression is up-regulated by statins through a mechanism involving PPARα, which is a statin target gene and might contribute to the triglyceride/non-esterified fatty acid-lowering properties of statins.
Journal ArticleDOI
In vivo effects of chronic contamination with depleted uranium on CYP3A and associated nuclear receptors PXR and CAR in the rat.
Maâmar Souidi,Yann Gueguen,Christine Linard,N. Dudoignon,Stéphane Grison,C. Baudelin,C. Marquette,Patrick Gourmelon,Jocelyne Aigueperse,Isabelle Dublineau +9 more
TL;DR: The results suggest that the stimulating effect of uranium on these enzymes might lead to hepatic or extrahepatic toxicity (or both) during drug treatment and then affect the entire organism.
Journal ArticleDOI
New Biological Indicators to Evaluate and Monitor Radiation-Induced Damage: An Accident Case Report
Jean-Marc Bertho,Laurence Roy,Maâmar Souidi,Marc Benderitter,Yann Gueguen,Jean-Jacques Lataillade,Marie Prat,T. Fagot,T. De Revel,Patrick Gourmelon +9 more
TL;DR: Several new biological indicators used to evaluate damage to the main physiological systems in a victim exposed accidentally to ionizing radiation demonstrated the importance of a multiparameter biological approach in the evaluation of radiation damage after accidental irradiation.
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In vivo effects of chronic contamination with depleted uranium on vitamin D3 metabolism in rat.
E. Tissandie,Yann Gueguen,Jean-Marc A. Lobaccaro,Line Grandcolas,Philippe Voisin,Jocelyne Aigueperse,Patrick Gourmelon,Maâmar Souidi +7 more
TL;DR: It is shown for the first time that DU affects both the vitamin D active form (1,25(OH)(2)D(3)) level and the Vitamin D receptor expression, and consequently could modulate the expression of cyp24a1 and vitamin D target genes involved in calcium homeostasis.
Journal ArticleDOI
Vitamin E decreases endogenous cholesterol synthesis and apo-AI-mediated cholesterol secretion in Caco-2 cells.
Jean-François Landrier,Jean-François Landrier,Erwan Gouranton,Erwan Gouranton,Emmanuelle Reboul,Emmanuelle Reboul,Nicolas Cardinault,Nicolas Cardinault,Claire El Yazidi,Claire El Yazidi,Christiane Malezet-Desmoulins,Christiane Malezet-Desmoulins,Marc André,Marc André,Marion Nowicki,Marion Nowicki,Maâmar Souidi,Patrick Borel,Patrick Borel +18 more
TL;DR: It is concluded that tocopherols impair the endogenous synthesis and apo-AI-mediated secretion of cholesterol in Caco-2 cells through a down-regulation of genes involved in the cholesterol synthesis pathway, resulting in down- regulation of CYP27A1 which diminishes oxysterol concentrations.