C
Charles Thomas
Researcher at French Institute of Health and Medical Research
Publications - 59
Citations - 6431
Charles Thomas is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Liver X receptor & Bile acid. The author has an hindex of 25, co-authored 52 publications receiving 5401 citations. Previous affiliations of Charles Thomas include University of Perugia & University of Burgundy.
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Journal ArticleDOI
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles Thomas,Antimo Gioiello,Lilia G. Noriega,Lilia G. Noriega,Axelle Strehle,Julien Oury,Giovanni Rizzo,Antonio Macchiarulo,Hiroyasu Yamamoto,Hiroyasu Yamamoto,Chikage Mataki,Chikage Mataki,Mark Pruzanski,Roberto Pellicciari,Johan Auwerx,Johan Auwerx,Kristina Schoonjans,Kristina Schoonjans +17 more
TL;DR: It is shown here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice, and suggested that pharmacological targeting of T GR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.
Journal ArticleDOI
Targeting bile-acid signalling for metabolic diseases
TL;DR: How the signalling functions of bile acids can be exploited in the development of drugs for obesity, type 2 diabetes, hypertriglyceridaemia and atherosclerosis, as well as other associated chronic diseases such as non-alcoholic steatohepatitis are reviewed.
Journal ArticleDOI
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation
Péter Bai,Péter Bai,Carles Cantó,Hugues Oudart,Attila Brunyanszki,Yana Cen,Charles Thomas,Hiroyasu Yamamoto,Aline Huber,Borbála Kiss,Riekelt H. Houtkooper,Kristina Schoonjans,Valérie Schreiber,Anthony A. Sauve,Josiane Ménissier-de Murcia,Johan Auwerx +15 more
TL;DR: The deletion of the poly(ADP-ribose) polymerase-1 (PARP-1) gene, encoding a major NAD(+)-consuming enzyme, increases NAD(+) content and SIRT1 activity in brown adipose tissue and muscle and the pharmacologic inhibition of PARP in vitro and in vivo is shown.
Journal ArticleDOI
The metabolic footprint of aging in mice
Riekelt H. Houtkooper,Carmen Argmann,Sander M. Houten,Carles Cantó,Ellen H. Jeninga,Pénélope Andreux,Charles Thomas,Raphael Doenlen,Kristina Schoonjans,Johan Auwerx +9 more
TL;DR: This work systemically integrated in vivo phenotyping with gene expression, biochemical analysis, and metabolomics, thereby identifying a distinguishing metabolic footprint of aging, and found glucose and fatty acid metabolism, and redox homeostasis are affected.
Journal ArticleDOI
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.
Thijs W.H. Pols,Mitsunori Nomura,Taoufiq Harach,Giuseppe Lo Sasso,Maaike H. Oosterveer,Charles Thomas,Giovanni Rizzo,Antimo Gioiello,Luciano Adorini,Roberto Pellicciari,Johan Auwerx,Kristina Schoonjans +11 more
TL;DR: It is demonstrated that activation of TGR5 in macrophages by 6α-ethyl-23(S)-methylcholic acid (6-EMCA, INT-777), a semisynthetic BA, inhibits proinflammatory cytokine production, an effect mediated by T GR5-induced cAMP signaling and subsequent NF-κB inhibition.