L
Lei Shi
Researcher at St. Jude Children's Research Hospital
Publications - 66
Citations - 3576
Lei Shi is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Medicine & Myeloid leukemia. The author has an hindex of 20, co-authored 53 publications receiving 2537 citations. Previous affiliations of Lei Shi include Abbott Laboratories & AbbVie.
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Journal ArticleDOI
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
Yu Liu,John Easton,Ying Shao,Jamie L. Maciaszek,Zhaoming Wang,Mark R. Wilkinson,Kelly McCastlain,Michael N. Edmonson,Stanley Pounds,Lei Shi,Xin Zhou,Xiaotu Ma,Edgar Sioson,Yongjin Li,Michael Rusch,Pankaj Gupta,Deqing Pei,Cheng Cheng,Malcolm A. Smith,Jaime M. Guidry Auvil,Daniela S. Gerhard,Mary V. Relling,Naomi J. Winick,Andrew J. Carroll,Nyla A. Heerema,Elizabeth A. Raetz,Meenakshi Devidas,Cheryl L. Willman,Richard C. Harvey,William L. Carroll,Kimberly P. Dunsmore,Stuart S. Winter,Brent L. Wood,Brian P. Sorrentino,James R. Downing,Mignon L. Loh,Stephen P. Hunger,Jinghui Zhang,Charles G. Mullighan +38 more
TL;DR: Using integrated genomic analysis of 264 T-ALL cases, 106 putative driver genes are identified and new mechanisms of coding and noncoding alteration are described, which suggests that different signaling pathways have distinct roles according to maturational stage.
Journal ArticleDOI
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
Michael F. Jarvis,Prisca Honore,Char Chang Shieh,Mark L. Chapman,Shailen K. Joshi,Xu Feng Zhang,Michael E. Kort,William A. Carroll,Brian E. Marron,Robert N. Atkinson,James Thomas,Dong Liu,Michael J. Krambis,Yi Liu,Steve McGaraughty,Katharine L. Chu,Rosemarie Roeloffs,Chengmin Zhong,Joseph P. Mikusa,Gricelda Hernandez,Donna M. Gauvin,Carrie Wade,Chang Zhu,Madhavi Pai,Marc J. C. Scanio,Lei Shi,Irene Drizin,Robert J. Gregg,Mark A. Matulenko,Ahmed A. Hakeem,Michael L. Gross,Matthew D. Johnson,Kennan C. Marsh,P. Kay Wagoner,James P. Sullivan,Connie R. Faltynek,Douglas S. Krafte +36 more
TL;DR: A-803467 is found, a sodium channel blocker that potently blocks tetrodotoxin-resistant currents and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons and produces significant antinociception in animal models of neuropathic and inflammatory pain.
Journal ArticleDOI
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.
Anna Andersson,Anna Andersson,Jing Ma,Jianmin Wang,Xiang Chen,Amanda Larson Gedman,Jinjun Dang,Joy Nakitandwe,Linda Holmfeldt,Matthew Parker,John Easton,Robert Huether,Richard W. Kriwacki,Michael Rusch,Gang Wu,Yongjin Li,Heather L. Mulder,Susana C. Raimondi,Stanley Pounds,Guolian Kang,Lei Shi,Jared Becksfort,Pankaj Gupta,Debbie Payne-Turner,Bhavin Vadodaria,Kristy Boggs,Donald Yergeau,Jayanthi Manne,Guangchun Song,Michael N. Edmonson,Panduka Nagahawatte,Lei Wei,C. Cheng,Deqing Pei,Rosemary Sutton,Nicola C. Venn,Albert Chetcuti,Amanda Rush,Daniel Catchpoole,Jesper Heldrup,Thoas Fioretos,Charles Lu,Li Ding,Ching-Hon Pui,Sheila A. Shurtleff,Charles G. Mullighan,Elaine R. Mardis,Richard K. Wilson,Tanja A. Gruber,Jinghui Zhang,James R. Downing +50 more
TL;DR: Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis and has one of the lowest frequencies of somatic mutations of any sequenced cancer, with the predominant leukemic clone carrying a mean of 1.3 non-silent mutations.
Journal ArticleDOI
PAX5 -driven subtypes of B-progenitor acute lymphoblastic leukemia
Zhaohui Gu,Michelle L. Churchman,Kathryn G. Roberts,Ian Moore,Xin Zhou,Joy Nakitandwe,Kohei Hagiwara,Stephane Pelletier,Sebastien Gingras,Hartmut Berns,Debbie Payne-Turner,Ashley Hill,Ilaria Iacobucci,Lei Shi,Stanley Pounds,Cheng Cheng,Deqing Pei,Chunxu Qu,Scott Newman,Meenakshi Devidas,Yunfeng Dai,Shalini C. Reshmi,Julie M. Gastier-Foster,Elizabeth A. Raetz,Michael J. Borowitz,Brent L. Wood,William L. Carroll,Patrick A. Zweidler-McKay,Karen R. Rabin,Leonard A. Mattano,Kelly W. Maloney,Alessandro Rambaldi,Orietta Spinelli,Jerald P. Radich,Mark D. Minden,Jacob M. Rowe,Selina M. Luger,Mark R. Litzow,Martin S. Tallman,Janis Racevskis,Yanming Zhang,Ravi Bhatia,Jessica Kohlschmidt,Krzysztof Mrózek,Clara D. Bloomfield,Wendy Stock,Steven M. Kornblau,Hagop M. Kantarjian,Marina Konopleva,Williams E. Evans,Sima Jeha,Ching-Hon Pui,Jun J. Yang,Elisabeth Paietta,James R. Downing,Mary V. Relling,Jinghui Zhang,Mignon L. Loh,Stephen P. Hunger,Charles G. Mullighan +59 more
TL;DR: Analysis of 1,988 cases of B-cell acute lymphoblastic leukemia characterizes 23 subtypes defined by genomic features and shows that two of the subtypes have frequent PAX5 alterations, demonstrating the utility of transcriptome sequencing to classify B-ALL.
Journal ArticleDOI
High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.
Kathryn G. Roberts,Zhaohui Gu,Debbie Payne-Turner,Kelly McCastlain,Richard C. Harvey,I-Ming Chen,Deqing Pei,Ilaria Iacobucci,Marcus B. Valentine,Stanley Pounds,Lei Shi,Yongjin Li,Jinghui Zhang,Cheng Cheng,Alessandro Rambaldi,Manuela Tosi,Orietta Spinelli,Jerald P. Radich,Mark D. Minden,Jacob M. Rowe,Selina M. Luger,Mark R. Litzow,Martin S. Tallman,Peter H. Wiernik,Ravi Bhatia,Ibrahim Aldoss,Jessica Kohlschmidt,Krzysztof Mrózek,Guido Marcucci,Clara D. Bloomfield,Wendy Stock,Stephen Kornblau,Hagop M. Kantarjian,Marina Konopleva,Elisabeth Paietta,Cheryl L. Willman,Charles G. Mullighan +36 more
TL;DR: Ph-like ALL is a highly prevalent subtype of ALL in adults and is associated with poor outcome, and trials comparing the addition of tyrosine kinase inhibitors to conventional therapy are required to evaluate the clinical utility of these agents in the treatment of Ph- like ALL.