Magda Wolna

TL;DR: It is shown that ferroportin expression in cardiomyocytes is essential to intracellular iron homeostasis and to normal cardiac function, and that the site of deposition of iron within the heart determines the severity with which it affects cardiac function.

TL;DR: These findings are the first demonstration of a cell-autonomous role for hepcidin in iron homeostasis and raise the possibility that such function may also be important in other tissues that express both hePCidin and ferroportin, such as the kidney and the brain.

TL;DR: In this article , the authors investigated anti-spike IgG antibody responses and correlates of protection after second doses of ChAdOx1 or BNT162b2 vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

TL;DR: Cyclin B is the only APC/CCdc20 substrate whose degradation at the onset of anaphase is necessary to prevent SAC reactivation, and the mutual activation of tension sensitive SAC and Cdk1 creates a bistable system that ensures complete activation of separase and total downregulation of Cdk2 when all chromosomes have bioriented.

TL;DR: In mammalian oocytes Shugoshin-like protein 2 (Sgol2) in addition to protecting cohesin, plays an important role in turning off the SAC, in promoting the congression and bi-orientation of bivalents on meiosis I spindles, in facilitating formation of K-fibers and in limiting bivalent stretching.