M
Malcolm J. Horsburgh
Researcher at University of Liverpool
Publications - 57
Citations - 4154
Malcolm J. Horsburgh is an academic researcher from University of Liverpool. The author has contributed to research in topics: Staphylococcus aureus & Virulence. The author has an hindex of 23, co-authored 50 publications receiving 3806 citations. Previous affiliations of Malcolm J. Horsburgh include University of Glasgow & University of Sheffield.
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Journal ArticleDOI
sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4.
TL;DR: It is suggested that SarA is not likely to be the effector in the overall sigmaB-mediated effect on agr expression, and the levels of SarA were found to be similar in strains 8325-4 and SH1000 (8325- 4 rsbU(+)) and sigB mutant derivatives of these strains.
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Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span
Ian Sabroe,Lynne R. Prince,Elizabeth C. Jones,Malcolm J. Horsburgh,Simon J. Foster,Stefanie N. Vogel,Steven K. Dower,Moira K. B. Whyte +7 more
TL;DR: TLR4 signaling presents itself as a pharmacological target that may allow therapeutic modulation of neutrophil survival by direct and indirect mechanisms at sites of inflammation.
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PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus.
TL;DR: PerR of S. aureus may act as a redox sentinel protein during infection, analogous to the in vitro activities of OxyR and PerR ofEscherichia coli and Bacillus subtilis, respectively, but it differs in its response to the metal balance within the cell and has the added capability of regulating iron uptake and storage.
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In Staphylococcus aureus, fur is an interactive regulator with PerR, contributes to virulence, and Is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis.
TL;DR: It is determined that Fur functions, either directly or indirectly, as an iron-dependent positive regulator of katA expression, which demonstrates the importance in vivo of iron homeostasis and oxidative stress resistance regulation in S. aureus.
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MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake
Malcolm J. Horsburgh,Stephen J. Wharton,Alan G. Cox,Eileen Ingham,Sharon J. Peacock,Simon J. Foster +5 more
TL;DR: The co‐ordinated regulation of metal ion homeostasis and oxidative stress resistance via the regulators MntR, PerR and Fur of S. aureus is discussed.