M
Malcolm K. Brenner
Researcher at Center for Cell and Gene Therapy
Publications - 632
Citations - 50064
Malcolm K. Brenner is an academic researcher from Center for Cell and Gene Therapy. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 109, co-authored 606 publications receiving 45233 citations. Previous affiliations of Malcolm K. Brenner include St. Jude Children's Research Hospital & Northwick Park Hospital.
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Journal ArticleDOI
795. The Use of Autologous LMP2-Specific Cytotoxic T Lymphocytes for the Treatment of Relapsed EBV +ve Hodgkin Disease and Non-Hodgkin Lymphoma
Catherine M. Bollard,Stephen Gottschalk,Elizabeth L. Buza,Helen Huls,Vicky Gresik,George Carrum,Malcolm K. Brenner,Cliona M. Rooney,Helen E. Heslop +8 more
TL;DR: In patients with identified LMP2-epitopes, measurement of IFN|[gamma]| secretion by CD8+ T cells after stimulation with appropriate LMP 2-peptides in ELISPOT assays showed a 4-25-fold increase in spot forming cells after infusions, in contrast, frequencies of CMV and superantigen-specific T cells did not increase.
Journal ArticleDOI
The “Side-Population” of Human Lymphoma Cells Have Increased Chemo-Resistance, Stem-Cell Like Properties and Are Potential Targets for Immunotherapy
Jessica A. Shafer,Ann M. Leen,Conrad Russell Y. Cruz,John Craddock,Helen E. Heslop,Cliona M. Rooney,Malcolm K. Brenner,Catherine M. Bollard,Aaron E. Foster +8 more
TL;DR: RT-PCR and immunohistochemistry both show that SP cells are HLA positive and have increased expression of MAGE-4, SSX2, Survivin and NY-ESO transcripts and protein compared to non-SP cells from the same tumor.
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Gene Transfer of IL-7R alpha (IL-7Rα) on Antigen-Specific Cytotoxic T Cells (CTLs) Restores Their Ability To Respond to IL-7 Cytokine.
Juan F. Vera,Valentina Hoyos,Barbara Savoldo,Concetta Quintarelli,G. Giordano-Attianese,Aaron E. Foster,Helen E. Heslop,Cliona M. Rooney,Malcolm K. Brenner,G. Dotti +9 more
TL;DR: IL-7Rα is found to be essentially undetectable in the model of EBV-specific CTL lines (EBV-CTLs), and the value of IL-7 for promoting proliferation of tumor- Specific CTLs after adoptive transfer remains questionable.
Journal ArticleDOI
Onward and upward for immuno-oncology
TL;DR: For many decades it has been clear that effectively harnessing the immune system for the treatment of cancer would provide an ideal array of cancer therapies possessing all the properties required to cure many human malignancies safely and effectively.