M
Malcolm K. Brenner
Researcher at Center for Cell and Gene Therapy
Publications - 632
Citations - 50064
Malcolm K. Brenner is an academic researcher from Center for Cell and Gene Therapy. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 109, co-authored 606 publications receiving 45233 citations. Previous affiliations of Malcolm K. Brenner include St. Jude Children's Research Hospital & Northwick Park Hospital.
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Journal ArticleDOI
CD45 monoclonal antibody-mediated cytolysis of human NK and T lymphoma cells
Gerald Wulf,Anita Boehnke,Bjoern Chapuy,Bertram Glass,Bernhard Hemmerlein,Roland Schroers,Malcolm K. Brenner,Lorenz Truemper +7 more
TL;DR: CD45 antibodies YTH24.5 and YTH54.12 have lytic activity against NK and T lymphoma cells via CDC and ADCC, are effective in a preclinical tumor model, and may be candidates for immunotherapeutic approaches to the treatment of humanNK and T cell lymphoma.
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CD30-Chimeric Antigen Receptor (CAR) T Cells for Therapy of Hodgkin Lymphoma (HL)
Carlos A. Ramos,Mrinalini Bilgi,Claudia Gerken,Olga Dakhova,Zhuyong Mei,Men-Feng Wu,Bambi Grilley,Adrian P. Gee,Cliona M. Rooney,Gianpietro Dotti,Barbara Savoldo,Helen E. Heslop,Malcolm K. Brenner +12 more
TL;DR: Inclusion of cytoreduction pre-infusion substantially improves CD30.CART expansion and appears associated with superior anti-tumor activity in relapsed patients, and preliminary results suggest a substantial improvement in efficacy.
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Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man.
Malcolm K. Brenner,Gerald Wulf,Donna Rill,Kang-Li Luo,Margaret A. Goodell,Zuyoung Mei,Ingrid Kuehnle,Michael P. Brown,Martin Pule,Helen E. Heslop,Robert A. Krance +10 more
TL;DR: It was found that all leukocyte subsets in peripheral blood were markedly diminished, but only the effect on the lymphoid compartment was sustained and marrow progenitor cells were spared from destruction after its systemic administration.
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The continuing contribution of gene marking to cell and gene therapy.
Siok-Keen Tey,Malcolm K. Brenner +1 more
TL;DR: Gene marking continues to have much to offer in terms of the authors' understanding of the behavior, fate, and safety of gene-modified cells in vivo.
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Cytologic diagnosis of respiratory syncytial virus infection in a bronchoalveolar lavage specimen from a bone marrow transplant recipient.
David M. Parham,Paula M. Bozeman,Cynthia S. Killian,Gopal Murti,Malcolm K. Brenner,Malcolm K. Brenner,Iftikar Hanif +6 more
TL;DR: Examination of bronchoalveolar lavage fluid from bone marrow transplant recipients should include a search for cytopathic changes compatible with RSV infection, and electron microscopy can be helpful in confirming this diagnosis.