M
Malcolm K. Brenner
Researcher at Center for Cell and Gene Therapy
Publications - 632
Citations - 50064
Malcolm K. Brenner is an academic researcher from Center for Cell and Gene Therapy. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 109, co-authored 606 publications receiving 45233 citations. Previous affiliations of Malcolm K. Brenner include St. Jude Children's Research Hospital & Northwick Park Hospital.
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Journal ArticleDOI
A comparison of double β-lactam combinations with netilmicin/ureidopenicillin regimens in the empirical therapy of febrile neutropenic patients
Christopher C. Kibbler,H. Grant Prentice,Roger Sage,A. Victor Hoffbrand,Malcolm K. Brenner,Parvin Mannan,Pauline Warner,Amrat Bhamra,Paul Noone +8 more
TL;DR: Results indicate that ceftazidime plus a ureidopenicillin would be adequate empirical therapy in situations where the concomitant use of nephrotoxic agents precludes the use of aminoglycoside containing combinations.
Journal ArticleDOI
Standardization of T-cell depletion in HLA matched bone marrow transplantation.
M. J. M. L. Gilmore,J. Patterson,K. Ivory,Malcolm K. Brenner,S. Graphakos,George Janossy,A. V. Hoffbrand,H. G. Prentice +7 more
TL;DR: New specifications for the use of Ficoll‐Metrizoate, the method used to calculate T‐lymphocyte depletion and the details of attempts to improve T‐depletion are reported.
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Gene-Marking studies of hematopoietic cells
TL;DR: With continuing advances in gene-marking technology, the value of the information provided by these studies increases, thereby ensuring their continued relevance to the field of gene transfer.
Journal ArticleDOI
Clonal Dynamics In Vivo of Virus Integration Sites of T Cells Expressing a Safety Switch.
Edmund C Chang,Edmund C Chang,Hao Liu,John A. West,Xiaoou Zhou,Xiaoou Zhou,Olga Dakhova,Olga Dakhova,David A. Wheeler,Helen E. Heslop,Malcolm K. Brenner,Gianpietro Dotti +11 more
TL;DR: It is proposed that suboptimal iC9 transgene expression is responsible for the incomplete elimination ofiC9-T cells and illustrated here by simple model how cis-modulatory influences of local genome context and T-cell receptor activation status at time of CID treatment contribute to stochastic sparing of iC 9- T cells.
Journal ArticleDOI
Expression of the human immunodeficiency virus type 1 primer binding sequence inhibits HIV-1 replication
Amer M. Kechli,Pamela Freiden,John J. Rossi,Malcolm K. Brenner,Mona A. Choueiry,J. Victor Garcia,Karen S. Slobod +6 more
TL;DR: It is proposed that the LTR-driven vector transcript containing 18 nucleotides identical to the HIV-1 PBS may act like an RNA decoy to titrate viral proteins such as reverse transcriptase and nucleocapsid away from genuine viral transcripts, thus compromising virus replication.