M
Malcolm K. Brenner
Researcher at Center for Cell and Gene Therapy
Publications - 632
Citations - 50064
Malcolm K. Brenner is an academic researcher from Center for Cell and Gene Therapy. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 109, co-authored 606 publications receiving 45233 citations. Previous affiliations of Malcolm K. Brenner include St. Jude Children's Research Hospital & Northwick Park Hospital.
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Journal ArticleDOI
Improving the safety of T-Cell therapies using an inducible caspase-9 gene
Xiaoou Zhou,Malcolm K. Brenner +1 more
TL;DR: The evolution of safety systems is reviewed, focusing on a suicide switch that can be expressed stably and efficiently in human T cells without impairing phenotype, function, or antigen specificity, allowing conditional dimerization in the presence of an otherwise bio-inert small molecule drug.
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Retrovirus-mediated gene transfer as an approach to analyze neuroblastoma relapse after autologous bone marrow transplantation.
Donna Rill,M. Buschle,Nicholas K. Foreman,C. Bartholomew,Robert C. Moen,Victor M. Santana,James N. Ihle,Malcolm K. Brenner +7 more
TL;DR: It is shown how retroviral-mediated gene transfer using the LNL6 vector may resolve the issue of relapse in disseminated neuroblastoma and how this technique could be used to analyze the efficacy of marrow purging techniques.
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Mobilization of CD34+ progenitor cells by granulocyte colony-stimulating factor in human immunodeficiency virus type 1-infected adults
Karen S. Slobod,Traci A. Bennett,Pamela Freiden,Amer M. Kechli,Nanna Howlett,Patricia M. Flynn,David R. Head,Deo Kumar Srivastava,James M. Boyett,Malcolm K. Brenner,J. Victor Garcia +10 more
TL;DR: It is concluded that G-CSF can safely mobilize CD34+ progenitor cells in HIV-1-infected subjects, and that these cells are suitable for consideration in gene-transfer strategies.
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Autoimmune disease induced by dendritic cell immunization against leukemia.
Marie Roskrow,Dagmar Dilloo,Nobuhiro Suzuki,Wanyung Zhong,Cliona M. Rooney,Cliona M. Rooney,Malcolm K. Brenner,Malcolm K. Brenner +7 more
TL;DR: The results suggest that the most effective strategies of immunotherapy against leukemia may also exceed the threshold of anergic cells, leading to a loss of self tolerance to normal self-antigens and the induction of an CD8+ anti-self effector response.
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Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes.
Ettore Biagi,Ettore Biagi,Gianpietro Dotti,Eric Yvon,Edward Lee,Martin Pule,Stephane Vigouroux,Stephen Gottschalk,Uday Popat,Raphael Rousseau,Malcolm K. Brenner +10 more
TL;DR: In this article, both CD40L and OX40L were expressed on B-CLL cells by exploiting the phenomenon of molecular transfer from fibroblasts overexpressing these ligands.