Mammen Chandy

TL;DR: From the 'Channg Cross and Westminster Medical School London UK IRCCS Maggiore Hospital, Milan Italy, Beth Israel Hospital, Boston USA, and the 'Institute of Thrombosis and Hemostasis Tel Hashomer, Israel.

TL;DR: Single-agent As2O3, as used in this series, in the management of newly diagnosed cases of APL, is associated with responses comparable with conventional chemotherapy regimens, and has minimal toxicity and can be administered on an outpatient basis after remission induction.

TL;DR: From the 'Charing Cross and Westminster Medical School, London, UK; 1RCCS Maggiore Hospital, Milan, Italy; Beth Israel Hospital, Boston USA; Universitv Hospital Leiden, The Netherlands; Research Centre of Medical Genetics, Moscow, The Russian Federation; WHO, Switzerland; Christian Medical College Hospital, Vellore, India; University of Lund, Malmö, Sweden.

TL;DR: Single-agent ATO as used in this study in the management of newly diagnosed cases of APL is safe and is associated with durable responses while results in the low-risk group are comparable to that reported with conventional therapy while additional interventions would probably be required in high-risk cases.

TL;DR: It is concluded that the GSTM1-null genotype predisposes to HVOD, and the sinusoidal endothelial cells and hepatocyte damage may be mediated by metabolites of busulfan through depletion of the cellular GSH pool.