K
Kwok Soon Wun
Researcher at Monash University, Clayton campus
Publications - 6
Citations - 833
Kwok Soon Wun is an academic researcher from Monash University, Clayton campus. The author has contributed to research in topics: T-cell receptor & Immune system. The author has an hindex of 5, co-authored 5 publications receiving 789 citations. Previous affiliations of Kwok Soon Wun include Australian Research Council.
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Journal ArticleDOI
CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor
Natalie A. Borg,Kwok Soon Wun,Lars Kjer-Nielsen,Matthew C.J. Wilce,Daniel G. Pellicci,Ruide Koh,Gurdyal S. Besra,Mandvi Bharadwaj,Dale I. Godfrey,James McCluskey,Jamie Rossjohn +10 more
TL;DR: The structure provides a basis for the interaction between the highly conserved NKT TCR α-chain and the CD1d–antigen complex that is typified in innate immunity, and indicates how variability of the N KT TCR β-chain can impact on recognition of other CD1D–antigens complexes.
Journal ArticleDOI
A molecular basis for the exquisite CD1d-restricted antigen specificity and functional responses of natural killer T cells
Kwok Soon Wun,Garth Cameron,Onisha Patel,Siew Siew Pang,Daniel G. Pellicci,Lucy C. Sullivan,Santosh Keshipeddy,Mary H. Young,Adam P Uldrich,Meena Thakur,Stewart K. Richardson,Amy R. Howell,Petr A. Illarionov,Andrew G. Brooks,Gurdyal S. Besra,James McCluskey,Laurent Gapin,Steven A. Porcelli,Dale I. Godfrey,Jamie Rossjohn +19 more
TL;DR: NKT TCR fine specificity against several closely related Ags, termed altered glycolipid ligands (AGLs), which differentially stimulate NKT cells are described, to provide a molecular basis for understanding how modifications in AGLs can result in striking alterations in the cellular response of N KT cells.
Journal ArticleDOI
A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR
Kwok Soon Wun,Natalie A. Borg,Lars Kjer-Nielsen,Travis Clarke Beddoe,Ruide Koh,Stewart K. Richardson,Meena Thakur,Amy R. Howell,James P. Scott-Browne,Laurent Gapin,Dale I. Godfrey,James McCluskey,Jamie Rossjohn +12 more
TL;DR: Although the structural footprint at the NKT TCR–CD1d–α-GalCer is small, the energetic footprint is smaller still, and reveals the minimal requirements for CD1d restriction.
Journal ArticleDOI
T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids.
Kwok Soon Wun,Josephine F. Reijneveld,Josephine F. Reijneveld,Tan Yun Cheng,Kristin Ladell,Adam P Uldrich,Jérôme Le Nours,Kelly L. Miners,James E. McLaren,Emma J. Grant,Oscar Haigh,Thomas S. Watkins,Sara Suliman,Sarah K. Iwany,Judith Jimenez,Roger Calderon,Kattya Lopez Tamara,Segundo R. Leon,Megan Murray,Jacob A. Mayfield,John D. Altman,Anthony W. Purcell,John J. Miles,Dale I. Godfrey,Stephanie Gras,David Price,Ildiko Van Rhijn,Ildiko Van Rhijn,D. Branch Moody,Jamie Rossjohn,Jamie Rossjohn +30 more
TL;DR: Rossjohn, Moody and colleagues show a unique form of autoreactivity with human CD1c molecules, whereby TCRs recognize a closed conformation of CD1 c molecules, which are loaded with a diverse array of ‘headless’ glycolipids.
Journal ArticleDOI
Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex.
Kwok Soon Wun,Fiona Ross,Onisha Patel,Gurdyal S. Besra,Steven A. Porcelli,Stewart K. Richardson,Santosh Keshipeddy,Amy R. Howell,Dale I. Godfrey,Jamie Rossjohn +9 more
TL;DR: Surprisingly, human NKT TCR recognition is more tolerant to modifications at the 4′-OH position in comparison with the 3′- OH position of α-GalCer, which contrasts the fine specificity of the mouse N KT TCR-CD1d-Ag recognition, which is an important consideration for therapeutic development and NKT cell physiology.