Manorama Tewari

TL;DR: Highly stable, polymer micelle assemblies known as filomicelles are used to compare the transport and trafficking of flexible filaments with spheres of similar chemistry and show that long-circulating vehicles need not be nanospheres.

TL;DR: In this article, proteomics analyses revealed that levels of the nucleoskeletal protein lamin-A scaled with tissue elasticity, as did levels of collagens in the extracellular matrix that determine E.

TL;DR: In this article, the authors show that actomyosin-driven nuclear rupture causes cytoplasmic mis-localization of DNA repair factors and excess DNA damage, which leads to cell-cycle arrest.

TL;DR: In this paper, the authors demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-transforming polymersomes, which are taken up passively by cultured cells after which the vesicles transform into micelles that allow endolysosomal escape and delivery of either siRNA into cytosol for mRNA knockdown or else AON into the nucleus for exon skipping within pre-mRNA.

TL;DR: It is proposed that, in the early embryonic heart tube, the signaling mechanism coordinating beats is mechanical rather than electrical, suggesting that mechanical signaling may initiate the very first heartbeats.