M
Manorama Tewari
Researcher at University of Pennsylvania
Publications - 14
Citations - 4439
Manorama Tewari is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Polymersome & Cell cycle checkpoint. The author has an hindex of 10, co-authored 14 publications receiving 3835 citations.
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Journal ArticleDOI
Shape effects of filaments versus spherical particles in flow and drug delivery.
Yan Geng,Paul Dalhaimer,Shenshen Cai,Richard K. Tsai,Manorama Tewari,Tamara Minko,Dennis E. Discher +6 more
TL;DR: Highly stable, polymer micelle assemblies known as filomicelles are used to compare the transport and trafficking of flexible filaments with spheres of similar chemistry and show that long-circulating vehicles need not be nanospheres.
Journal ArticleDOI
Nuclear lamin-A Scales With Tissue Stiffness and Enhances Matrix-Directed Differentiation
Joe Swift,Irena L. Ivanovska,Amnon Buxboim,Takamasa Harada,P.C. Dave P. Dingal,Joel Pinter,J. David Pajerowski,Kyle R. Spinler,Jae-Won Shin,Manorama Tewari,Florian Rehfeldt,David W. Speicher,Dennis E. Discher,Dennis E. Discher +13 more
TL;DR: In this article, proteomics analyses revealed that levels of the nucleoskeletal protein lamin-A scaled with tissue elasticity, as did levels of collagens in the extracellular matrix that determine E.
Journal ArticleDOI
Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.
Sangkyun Cho,Manasvita Vashisth,Amal Abbas,Stephanie Majkut,Kenneth Vogel,Yuntao Xia,Irena L. Ivanovska,Jerome Irianto,Manorama Tewari,Kuangzheng Zhu,Elisia D. Tichy,Foteini Mourkioti,Hsin-Yao Tang,Roger A. Greenberg,Benjamin L. Prosser,Dennis E. Discher +15 more
TL;DR: In this article, the authors show that actomyosin-driven nuclear rupture causes cytoplasmic mis-localization of DNA repair factors and excess DNA damage, which leads to cell-cycle arrest.
Journal ArticleDOI
Polymersome delivery of siRNA and antisense oligonucleotides.
Younghoon Kim,Manorama Tewari,J. David Pajerowski,Shenshen Cai,Shamik Sen,Jason H. Williams,Shashank R. Sirsi,Gordon J. Lutz,Dennis E. Discher +8 more
TL;DR: In this paper, the authors demonstrate loading and functional delivery of RNAi and AON with non-ionic, nano-transforming polymersomes, which are taken up passively by cultured cells after which the vesicles transform into micelles that allow endolysosomal escape and delivery of either siRNA into cytosol for mRNA knockdown or else AON into the nucleus for exon skipping within pre-mRNA.
Journal ArticleDOI
Mechanical signaling coordinates the embryonic heartbeat
Kevin Chiou,Jason W. Rocks,Christina Yingxian Chen,Sangkyun Cho,KE Koen Merkus,Anjali Rajaratnam,Patrick Robison,Manorama Tewari,Kenneth Vogel,Stephanie Majkut,Benjamin L. Prosser,Dennis E. Discher,Andrea J. Liu +12 more
TL;DR: It is proposed that, in the early embryonic heart tube, the signaling mechanism coordinating beats is mechanical rather than electrical, suggesting that mechanical signaling may initiate the very first heartbeats.