M
Manuel Feinauer
Researcher at German Cancer Research Center
Publications - 2
Citations - 47
Manuel Feinauer is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Cancer & Brain metastasis. The author has an hindex of 2, co-authored 2 publications receiving 13 citations. Previous affiliations of Manuel Feinauer include University Hospital Heidelberg.
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Journal ArticleDOI
Local blood coagulation drives cancer cell arrest and brain metastasis in a mouse model
Manuel Feinauer,Manuel Feinauer,Stefan W. Schneider,Anna S. Berghoff,Anna S. Berghoff,Anna S. Berghoff,Jose Ramon Robador,Cedric Tehranian,Cedric Tehranian,Matthia A. Karreman,Matthia A. Karreman,Varun Venkataramani,Varun Venkataramani,Varun Venkataramani,Gergely Solecki,Gergely Solecki,Gergely Solecki,Julia Grosch,Julia Grosch,Katharina Gunkel,Katharina Gunkel,Bogdana Kovalchuk,Bogdana Kovalchuk,Frank Thomas Mayer,Manuel Fischer,Michael O. Breckwoldt,Maik Brune,Yannik Schwab,Wolfgang Wick,Wolfgang Wick,Alexander Bauer,Frank Winkler,Frank Winkler +32 more
TL;DR: In vivo multiphoton laser-scanning microscopy of the entire brain metastatic cascade allowed unprecedented insights into how blood clot formation and von Willebrand factor deposition determine the arrest of circulating cancer cells and subsequent brain colonization in mice, discovering a novel and specific mechanism that is crucial for brain colonization.
Journal ArticleDOI
Identification and characterization of cancer cells that initiate metastases to the brain and other organs
Anna S. Berghoff,Anna S. Berghoff,Anna S. Berghoff,Yunxiang Liao,Yunxiang Liao,Matthia A. Karreman,Matthia A. Karreman,Ayseguel Ilhan-Mutlu,Katharina Gunkel,Katharina Gunkel,Martin R. Sprick,Christian Eisen,Tobias Kessler,Tobias Kessler,Matthias Osswald,Matthias Osswald,Susanne Wünsche,Susanne Wünsche,Manuel Feinauer,Manuel Feinauer,Brunhilde Gril,Frederic Marmé,Laura Michel,Zuszanna Bago-Horvath,Felix Sahm,Felix Sahm,Natalia Becker,Michael O. Breckwoldt,Gergely Solecki,Gergely Solecki,Miriam Gömmel,Miriam Gömmel,Lulu Huang,Lulu Huang,Petra Rübmann,Carina M. Thome,Miriam Ratliff,Miriam Ratliff,Andreas Trumpp,P. S. Steeg,Matthias Preusser,Wolfgang Wick,Wolfgang Wick,Frank Winkler,Frank Winkler +44 more
TL;DR: The data identify temporary slow-cycling breast cancer cells as the dominant source of brain and other metastases and demonstrates that this can lead to better understanding of BMIC-relevant pathways, including potential new approaches to prevent BM in patients.