Manyi Yang

TL;DR: The first comprehensive genomic survey of the immune gene repertoire of the Amphioxus Branchiostoma floridae suggests that the amphioxus, a species without vertebrate-type adaptive immunity, holds extraordinary innate complexity and diversity.

TL;DR: This study provides evidence for the immune-relation of amphioxus V-type TLRs, and suggests that Amphioxus TLR1 and MyD88 represent a basic evolutionary pathway.

TL;DR: It is found that B. belcheri tsingtauense SARM was localized in mitochondria and could attenuate the TLR signaling via interacting with amphioxus MyD88 and tumor necrosis receptor associated factor 6, suggesting its primitive role in neural development and a potential physiologic role in immunity.

TL;DR: Comparisons of four distinct amphioxus TRAF groups suggest that genomic duplication and functional divergence of the TRAF family are important for the current form of the TNF-associated factor-mediated signaling pathways in humans.

TL;DR: The findings supported the idea that this pathway may represent a chordate-specific innovation in the evolution of the complement system, and concluded that amphioxus have developed a functional ficolin-complement pathway.