M
Meiling Dong
Researcher at Sun Yat-sen University
Publications - 33
Citations - 1860
Meiling Dong is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Gene & Immune system. The author has an hindex of 20, co-authored 30 publications receiving 1715 citations. Previous affiliations of Meiling Dong include Chinese Ministry of Education.
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Journal ArticleDOI
Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity
Shengfeng Huang,Shaochun Yuan,Lei Guo,Yanhong Yu,Jun Li,Tao Wu,Tong Liu,Manyi Yang,Kui Wu,Huiling Liu,Jin Ge,Yingcai Yu,Huiqing Huang,Meiling Dong,Cuiling Yu,Shangwu Chen,Anlong Xu +16 more
TL;DR: The first comprehensive genomic survey of the immune gene repertoire of the Amphioxus Branchiostoma floridae suggests that the amphioxus, a species without vertebrate-type adaptive immunity, holds extraordinary innate complexity and diversity.
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Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: striking similarities and obvious differences with mammals.
Bin Lin,Shangwu Chen,Zhen Cao,Yiqun Lin,Dunzhou Mo,Haibo Zhang,Juda Gu,Meiling Dong,Zehuan Liu,Anlong Xu +9 more
TL;DR: The first systematic study of zebrafish immune response to Aeromonas salmonicida and Staphylococcus aureus is presented, implying evolutionary conserved mechanisms among fish and mammals.
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A Short-Form C-Type Lectin from Amphioxus Acts as a Direct Microbial Killing Protein via Interaction with Peptidoglycan and Glucan
Yanhong Yu,Yingcai Yu,Huiqing Huang,Kaixia Feng,Minming Pan,Shaochun Yuan,Shengfeng Huang,Tao Wu,Lei Guo,Meiling Dong,Shangwu Chen,Anlong Xu +11 more
TL;DR: Findings suggested that AmphiCTL1 acted as a direct microbial killing C-type lectin through binding microbial targets via interaction with peptidoglycan and glucan, which may be an evolutionarily primitive form of antimicrobial protein involved in lectin-mediated innate immunity.
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The phylogenetic analysis of tetraspanins projects the evolution of cell-cell interactions from unicellular to multicellular organisms.
Shengfeng Huang,Shaochun Yuan,Meiling Dong,Jing Su,Cuiling Yu,Yang Shen,Xiaojin Xie,Yanhong Yu,Xuesong Yu,Shangwu Chen,Shicui Zhang,Pierre Pontarotti,Anlong Xu +12 more
TL;DR: The study of tetraspanin in a phylogenetic context helps to understand the evolution of intercellular interactions and it is suggested that t Petraspanins play important roles in the unicell-to-multicell transition.
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Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes
Shengfeng Huang,Zelin Chen,Xinyu Yan,Ting Yu,Guangrui Huang,Qingyu Yan,Pierre Pontarotti,Hongchen Zhao,Jie Li,Ping Yang,Ruihua Wang,Rui Li,Xin Tao,Ting Deng,Yi-Quan Wang,Guang Li,Qiujin Zhang,Sisi Zhou,Leiming You,Shaochun Yuan,Yonggui Fu,Fenfang Wu,Meiling Dong,Shangwu Chen,Anlong Xu +24 more
TL;DR: It is suggested, through comparison with multiple lancelet genomes, that ancient vertebrates experienced high rates of protein evolution, genome rearrangement and domain shuffling and that these rates greatly slowed down after the divergence of jawed and jawless vertebrates.