T
Tong Liu
Researcher at Sun Yat-sen University
Publications - 8
Citations - 483
Tong Liu is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 4, co-authored 4 publications receiving 444 citations.
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Journal ArticleDOI
Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity
Shengfeng Huang,Shaochun Yuan,Lei Guo,Yanhong Yu,Jun Li,Tao Wu,Tong Liu,Manyi Yang,Kui Wu,Huiling Liu,Jin Ge,Yingcai Yu,Huiqing Huang,Meiling Dong,Cuiling Yu,Shangwu Chen,Anlong Xu +16 more
TL;DR: The first comprehensive genomic survey of the immune gene repertoire of the Amphioxus Branchiostoma floridae suggests that the amphioxus, a species without vertebrate-type adaptive immunity, holds extraordinary innate complexity and diversity.
Journal ArticleDOI
An amphioxus TLR with dynamic embryonic expression pattern responses to pathogens and activates NF-κB pathway via MyD88
Shaochun Yuan,Shengfeng Huang,Wei Zhang,Tao Wu,Meiling Dong,Yanhong Yu,Tong Liu,Kui Wu,Huiling Liu,Manyi Yang,Hongwei Zhang,Anlong Xu +11 more
TL;DR: This study provides evidence for the immune-relation of amphioxus V-type TLRs, and suggests that Amphioxus TLR1 and MyD88 represent a basic evolutionary pathway.
Journal ArticleDOI
Genomic and Functional Uniqueness of the TNF Receptor-Associated Factor Gene Family in Amphioxus, the Basal Chordate
Shaochun Yuan,Tong Liu,Shengfeng Huang,Tao Wu,Ling Huang,Huiling Liu,Xin Tao,Manyi Yang,Kui Wu,Yanhong Yu,Meiling Dong,Anlong Xu +11 more
TL;DR: Comparisons of four distinct amphioxus TRAF groups suggest that genomic duplication and functional divergence of the TRAF family are important for the current form of the TNF-associated factor-mediated signaling pathways in humans.
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Bbt-TNFR1 and Bbt-TNFR2, two tumor necrosis factor receptors from Chinese amphioxus involve in host defense.
Shaochun Yuan,Yanhong Yu,Shengfeng Huang,Tong Liu,Tao Wu,Meiling Dong,Shangwu Chen,Yingcai Yu,Anlong Xu +8 more
TL;DR: Two novel tumor necrosis factor receptors isolated from Chinese amphioxus were isolated and showed that they were regulated during development and finally had high expression in mucosa-rich tissues in adult stage, and may involve in the host defense of Chinese Amphioxus via distinct fashions.
Journal ArticleDOI
CD40×HER2 bispecific antibody overcomes the CCL2-induced trastuzumab resistance in HER2-positive gastric cancer
Weilin Sun,Xi Wang,Dao-Han Wang,Li Lu,Hai Lin,Zhaoxiong Zhang,Yangpu Jia,X. Nie,Tong Liu,Weihua Fu +9 more
TL;DR: A novel mechanism of trastuzumab resistance in HER2-positive GC is revealed via the CCL2-ZC3H12A-TRAF6/3 signaling axis, and a CD40 ×HER2 bsAb is presented which showed great antitumor efficacy with few irAEs.