M
Mara Leone
Researcher at Leiden University
Publications - 8
Citations - 328
Mara Leone is an academic researcher from Leiden University. The author has contributed to research in topics: Penetration (firestop) & Cationic liposome. The author has an hindex of 7, co-authored 8 publications receiving 228 citations.
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Journal ArticleDOI
Dissolving microneedle patches for dermal vaccination
TL;DR: This review focuses on dissolving microneedles that after penetration into the skin dissolve releasing the encapsulated antigen, and the immunogenicity of antigens formulated in dissolvingmicroneedle are addressed.
Journal ArticleDOI
Development of PLGA nanoparticle loaded dissolving microneedles and comparison with hollow microneedles in intradermal vaccine delivery.
Juha Mönkäre,Maria Pontier,Eveline E.M. van Kampen,Guangsheng Du,Mara Leone,Stefan Romeijn,M. Reza Nejadnik,Conor O'Mahony,Bram Slütter,Wim Jiskoot,Joke A. Bouwstra +10 more
TL;DR: Several critical formulation parameters are identified for the further development of NP‐loaded dissolving MNs loaded with PLGA nanoparticles co‐encapsulating ovalbumin (OVA) and poly(I:C) for intradermal immunisation.
Journal ArticleDOI
Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment.
Mara Leone,Marjolein I. Priester,Stefan Romeijn,M. Reza Nejadnik,Juha Mönkäre,Conor O'Mahony,Wim Jiskoot,Gideon F.A. Kersten,Joke A. Bouwstra +8 more
TL;DR: Results suggest that the polydimethylsiloxane mold design has an impact on the manufacturing ofdMNs, the increase in antigen loading in dMNs affects the microneedle dissolution and d MNs are a valid alternative for vaccine administration over conventional injection.
Journal ArticleDOI
Universal Applicator for Digitally-Controlled Pressing Force and Impact Velocity Insertion of Microneedles into Skin.
Mara Leone,Bart H van Oorschot,M. Reza Nejadnik,Andrea Bocchino,Matteo Rosato,Gideon F.A. Kersten,Conor O'Mahony,Joke A. Bouwstra,Koen van der Maaden +8 more
TL;DR: Data demonstrate that an applicator is an important tool to determine optimal application conditions with ex vivo human skin, and microneedles pierced the skin more efficiently when applied by impact application as compared to application via pressing force.
Journal ArticleDOI
Hyaluronan molecular weight: Effects on dissolution time of dissolving microneedles in the skin and on immunogenicity of antigen.
TL;DR: The aim of this study was to investigate the effect of the molecular weight of hyaluronan, a polymer widely used in the fabrication of dMNs, on the dissolution of microneedles in the skin in time as well as the antibody response in mice and T-cell activation in vitro.