Hyaluronan-based dissolving microneedles with high antigen content for intradermal vaccination: Formulation, physicochemical characterization and immunogenicity assessment.
Mara Leone,Marjolein I. Priester,Stefan Romeijn,M. Reza Nejadnik,Juha Mönkäre,Conor O'Mahony,Wim Jiskoot,Gideon F.A. Kersten,Joke A. Bouwstra +8 more
TLDR
Results suggest that the polydimethylsiloxane mold design has an impact on the manufacturing ofdMNs, the increase in antigen loading in dMNs affects the microneedle dissolution and d MNs are a valid alternative for vaccine administration over conventional injection.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2019-01-01 and is currently open access. It has received 37 citations till now.read more
Citations
More filters
Journal ArticleDOI
Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies.
TL;DR: This overview on skin delivery considers the evolution of the principles of percutaneous ab-sorption and skin products from ancient times to today and the development of technologies to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond.
Journal ArticleDOI
Enhancement strategies for transdermal drug delivery systems: current trends and applications.
TL;DR: In this paper, the authors reviewed current trends and future applications of transdermal technologies, with specific focus on providing a comprehensive understanding of Transdermal drug delivery systems and enhancement strategies.
Journal ArticleDOI
Recent advances in microneedle composites for biomedical applications: Advanced drug delivery technologies.
TL;DR: This review summarizes characterization, fabrications, biological applications and challenges of microneedles with respect to an assortment of techniques, their modifications, clinical trials and regulatory perspectives period of 2000-2019.
Journal ArticleDOI
Microneedle Mediated Transdermal Delivery of Protein, Peptide and Antibody Based Therapeutics: Current Status and Future Considerations
TL;DR: The true potential of MNs as a drug delivery device for biopharmaceuticals will not only rely on acceptance from prescribers, patients and the regulatory authorities, but the ability to upscale MN manufacture in a cost-effective manner and the long term safety of MN application.
Journal ArticleDOI
Hyaluronic acid based microneedle array: Recent applications in drug delivery and cosmetology.
Ivy Saha,Vineet Kumar Rai +1 more
TL;DR: The recent advancements in HA-microneedles based application on drug delivery and cosmetology are presented and its bio-degradation pathways, the receptors on which HA and its derivatives interact, the biological half-lives, and their importance as useful materials for various applications are highlighted.
References
More filters
Journal ArticleDOI
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Christian Termeer,Frauke Benedix,Jonathon Sleeman,Christina Fieber,Ursula Voith,Thomas Ahrens,Kensuke Miyake,Marina A. Freudenberg,Christopher Galanos,Jan-Christoph Simon +9 more
TL;DR: This is the first report that polysaccharide degradation products of the extracellular matrix produced during inflammation might serve as an endogenous ligand for the TLR-4 complex on DCs.
Journal ArticleDOI
Microneedles for drug and vaccine delivery.
TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
Journal ArticleDOI
Protein aggregation and its inhibition in biopharmaceutics
TL;DR: This article intends to discuss protein aggregation and its related mechanisms, methods characterizingprotein aggregation, factors affecting protein aggregation, and possible venues in aggregation prevention/inhibition in various stages of protein drug development.
Journal ArticleDOI
Dissolving microneedles for transdermal drug delivery.
TL;DR: It is concluded that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery and leave behind no biohazardous sharp medical waste.
Journal ArticleDOI
Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers
TL;DR: The ability of a particular additive to preserved the aqueous structure of dehydrated proteins and poly-L-lysine upon dehydration correlates directly with its ability to preserve the activity of lactate dehydrogenase, a labile enzyme, during drying.