Hyaluronan molecular weight: Effects on dissolution time of dissolving microneedles in the skin and on immunogenicity of antigen.
TLDR
The aim of this study was to investigate the effect of the molecular weight of hyaluronan, a polymer widely used in the fabrication of dMNs, on the dissolution of microneedles in the skin in time as well as the antibody response in mice and T-cell activation in vitro.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2020-04-15 and is currently open access. It has received 26 citations till now.read more
Citations
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Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing.
TL;DR: In this article, the current state of knowledge on immune cell functions during skin tissue regeneration is first discussed, and then advanced technologies used to design immunomodulatory hydrogels for controlling macrophages' polarization are summarized.
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An Overview of Biopolymeric Electrospun Nanofibers Based on Polysaccharides for Wound Healing Management.
Andreea-Teodora Iacob,Maria Drăgan,Oana-Maria Ionescu,Lenuța Profire,Anton Ficai,Ecaterina Andronescu,Luminița Georgeta Confederat,Dan Lupașcu +7 more
TL;DR: This review of the formulation of electrospun nanofibers based on polysaccharides as dressings useful in wound healing was based on the ever-growing research in this field, research that highlighted many advantages of the nanofibrillary network, but also a marked versatility in terms of numerous active substances that can be incorporated for rapid and infection-free tissue regeneration.
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Microneedle-Mediated Vaccination: Innovation and Translation.
TL;DR: In this article, a review of the development and application of microneedles for vaccination based on different delivery strategies is presented, and the potential for its application including opportunities and challenges are further discussed.
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Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease.
Qinying Yan,Weiwei Wang,Jiaqi Weng,Zhenghan Zhang,Li-Na Yin,Qingliang Yang,Fangyuan Guo,Xingang Wang,Chen Fan,Gensheng Yang +9 more
TL;DR: Results demonstrated that this predesigned DMNP is a promising alternative to deliver Hup A transdermally for the treatment of AD.
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Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges.
Prateek Ranjan Yadav,Monika Nasrin Munni,Lauryn Campbell,Golam Mostofa,Lewis James Dobson,Morayo Shittu,Sudip K. Pattanayek,Md. Jasim Uddin,Diganta Bhusan Das +8 more
TL;DR: In this paper, the authors focused on the key points (e.g., choice polymeric MNs) for the translation of microneedles from laboratory to clinical practice.
References
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How dying cells alert the immune system to danger
Hajime Kono,Kenneth L. Rock +1 more
TL;DR: Current knowledge of cell death and repair processes in the host and their importance to host defence and disease pathogenesis has only been appreciated relatively recently is reviewed.
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Dendritic cells: unique leukocyte populations which control the primary immune response.
TL;DR: Steinman and Cohn identified mouse spleen DC in 19731 and initiated a series of experiments that established lymphoid tissue–derived DC as potent stimulators of primary cancer.
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Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Christian Termeer,Frauke Benedix,Jonathon Sleeman,Christina Fieber,Ursula Voith,Thomas Ahrens,Kensuke Miyake,Marina A. Freudenberg,Christopher Galanos,Jan-Christoph Simon +9 more
TL;DR: This is the first report that polysaccharide degradation products of the extracellular matrix produced during inflammation might serve as an endogenous ligand for the TLR-4 complex on DCs.
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Hyaluronan fragments: an information-rich system.
TL;DR: The vast range of activities of hyaluronan polymers is reviewed here, in order to determine if patterns can be detected that would provide insight into their production and regulation.
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Hyaluronan as an Immune Regulator in Human Diseases
TL;DR: This review focuses on the role of hyaluronan as an immune regulator in human diseases through regulating inflammatory cell recruitment, release of inflammatory cytokines, and cell migration.