Marc Cloutier

TL;DR: This review presents the four principle non‐human animal models of TO/obstruction and discusses them in relation to their utility in elucidating lung development, in remedying congenital diaphragmatic hernia (CDH), as well as in investigating the stretching effects on growth and remodeling of the fine vasculature.

TL;DR: In this paper, the authors select plasma from a cohort of convalescent patients with COVID-19 and selectively deplete immunoglobulin A, M or G before testing the remaining neutralizing capacity of the depleted plasma.

TL;DR: It is found that depletion of immunoglobulin M was associated with the most substantial loss of virus neutralization, followed by immunoglOBulin G, which may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of IgM.

TL;DR: In vitro-produced polyclonal IgGs were bearing higher levels of bisecting GlcNAc known to affect the effector functions of therapeutic antibodies, highlighting the need for monitoring of the glycoform distribution in antibodies produced in vitro.

TL;DR: It is suggested that surgically applied stretching quickly enhances the expression of specific angiogenesis and vessel maintenance genes, which seems to result in the maturation and organization of a more extensive and complex capillary network.