S
Shilei Ding
Researcher at Université de Montréal
Publications - 87
Citations - 3132
Shilei Ding is an academic researcher from Université de Montréal. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 26, co-authored 58 publications receiving 2077 citations. Previous affiliations of Shilei Ding include McGill University & Jewish General Hospital.
Papers
More filters
Journal ArticleDOI
IFITM proteins restrict viral membrane hemifusion
Kun Li,Ruben M. Markosyan,Yi-Min Zheng,Ottavia Golfetto,Brittani L. Bungart,Minghua Li,Shilei Ding,Yuxian He,Chen Liang,James C. Lee,Enrico Gratton,Fredric S. Cohen,Shan-Lu Liu +12 more
TL;DR: It is demonstrated that IFITM proteins suppress viral membrane fusion before the creation of hemifusion, and suggested that they may do so by reducing membrane fluidity and conferring a positive spontaneous curvature in the outer leaflets of cell membranes.
Journal ArticleDOI
The Interferon-Inducible MxB Protein Inhibits HIV-1 Infection
Zhenlong Liu,Qinghua Pan,Shilei Ding,Shilei Ding,Jin Qian,Jin Qian,Fengwen Xu,Jinming Zhou,Shan Cen,Fei Guo,Chen Liang,Chen Liang +11 more
TL;DR: The interferon-inducible myxovirus resistance (Mx) proteins play important roles in combating a wide range of virus infections, but the antiviral activity of MxB is less well established.
Journal ArticleDOI
Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike.
Jérémie Prévost,Romain Gasser,Guillaume Beaudoin-Bussières,Jonathan Richard,Ralf Duerr,Annemarie Laumaea,Sai Priya Anand,Guillaume Goyette,Mehdi Benlarbi,Shilei Ding,Halima Medjahed,Antoine Lewin,Josée Perreault,Tony Tremblay,Gabrielle Gendron-Lepage,Nicolas Gauthier,Marc Carrier,Diane Marcoux,Alain Piché,Myriam Lavoie,Alexandre Benoit,Vilayvong Loungnarath,Gino Brochu,Elie Haddad,Hannah D. Stacey,Matthew S. Miller,Marc Desforges,Pierre J. Talbot,Graham T. Gould Maule,Marceline Côté,Christian Therrien,Bouchra Serhir,Renée Bazin,Michel Roger,Andrés Finzi,Andrés Finzi +35 more
TL;DR: While most of individuals develop neutralizing antibodies within two weeks of infection, the level ofneutralizing activity is significantly decreased over time, highlighting the importance of studying the persistence of neutralizing activity upon natural SARS-CoV-2 infection.
Journal ArticleDOI
The N-Terminal Region of IFITM3 Modulates Its Antiviral Activity by Regulating IFITM3 Cellular Localization
Rui Jia,Qinghua Pan,Shilei Ding,Shilei Ding,Liwei Rong,Shan-Lu Liu,Yunqi Geng,Wentao Qiao,Chen Liang,Chen Liang +9 more
TL;DR: It is found that deleting this 21-amino-acid region relocates IFITM3 from the endosomal compartments to the cell periphery and suggests that its N-terminal region is specifically required for controlling pH-dependent viruses.
Journal ArticleDOI
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.
Jingyou Yu,Minghua Li,Jordan Maximillian Wilkins,Shilei Ding,Talia H. Swartz,Anthony M. Esposito,Yi-Min Zheng,Eric O. Freed,Chen Liang,Benjamin K. Chen,Shan-Lu Liu +10 more
TL;DR: Overall, this study uncovers a mechanism by which IFITM proteins specifically antagonize HIV-1 Env to restrict HIV- 1 infection and provides insight into the specialized role of IFITMs in HIV infection.