M
Marc E. Horowitz
Researcher at Baylor College of Medicine
Publications - 94
Citations - 7030
Marc E. Horowitz is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Sarcoma & Ewing's sarcoma. The author has an hindex of 43, co-authored 93 publications receiving 6871 citations. Previous affiliations of Marc E. Horowitz include St. Jude Children's Research Hospital & Rhode Island Hospital.
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Journal ArticleDOI
Age, thymopoiesis, and CD4+ t-lymphocyte regeneration after intensive chemotherapy
Crystal L. Mackall,Thomas A. Fleisher,Margaret R. Brown,Mary P. Andrich,Clara C. Chen,Irwin M. Feuerstein,Marc E. Horowitz,Ian T. Magrath,Aziza T. Shad,Seth M. Steinberg,Leonard H. Wexler,Ronald E. Gress +11 more
TL;DR: Thymus-dependent regeneration of CD4+ T lymphocytes occurs primarily in children, whereas even young adults have deficiencies in this pathway, and the results suggest that rapid T-cell regeneration requires residual thymic function in patients receiving high-dose chemotherapy.
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Postoperative Chemotherapy and Delayed Radiation in Children Less Than Three Years of Age With Malignant Brain Tumors
Patricia K. Duffner,Marc E. Horowitz,Jeffrey P. Krischer,Henry S. Friedman,Peter C. Burger,Michael E. Cohen,Robert A. Sanford,Raymond K. Mulhern,Hector E. James,Carolyn R. Freeman,F. Glen Seidel,Larry E. Kun +11 more
TL;DR: Chemotherapy appears to be an effective primary postoperative treatment for many malignant brain tumors in young children and a comparison of cognitive evaluations obtained at base line and after one year of chemotherapy revealed no evidence of deterioration in cognitive function.
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Lymphocyte depletion during treatment with intensive chemotherapy for cancer.
Crystal L. Mackall,Thomas A. Fleisher,Margaret R. Brown,Ian T. Magrath,Aziza T. Shad,Marc E. Horowitz,Leonard H. Wexler,Melissa Adde,Linda L. McClure,Ronald E. Gress +9 more
TL;DR: Based on the history of opportunistic complications in patients with other disorders who display similar degrees of CD4+ T-cell lymphopenia and preliminary observations in this population, immune incompetence could surface as a dose-limiting toxicity for highly dose-intensive chemotherapy regimens.
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Second malignancies after Ewing's sarcoma: radiation dose-dependency of secondary sarcomas.
John F. Kuttesch,Leonard H. Wexler,Robert B. Marcus,Diane L. Fairclough,Linda Weaver-McClure,Margaret White,Lion Mao,Thomas F. DeLaney,Charles B. Pratt,Marc E. Horowitz,Larry E. Kun +10 more
TL;DR: The overall risk of second malignancies after Ewing's sarcoma is similar to that associated with treatment for other childhood cancers, and the radiation dose-dependency of secondary sarcomas justifies modification in therapy to reduce radiation doses.
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Hearing loss in children and young adults receiving cisplatin with or without prior cranial irradiation.
Michael J. Schell,V.A. McHaney,Alexander A. Green,Larry E. Kun,F A Hayes,Marc E. Horowitz,William H. Meyer +6 more
TL;DR: It is concluded that early increases in hearing threshold at a stimulus frequency of 4,000 Hz indicate probable subsequent deficits at lower frequencies, especially in young children with CNS tumors who have received cranial irradiation.