M
Marc Lübberstedt
Researcher at Charité
Publications - 10
Citations - 781
Marc Lübberstedt is an academic researcher from Charité. The author has contributed to research in topics: Bioreactor & Embryonic stem cell. The author has an hindex of 10, co-authored 10 publications receiving 699 citations.
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Journal ArticleDOI
HepaRG Human Hepatic Cell Line Utility as a Surrogate for Primary Human Hepatocytes in Drug Metabolism Assessment in Vitro
Marc Lübberstedt,Ursula Müller-Vieira,Manuela Mayer,Klaus M. Biemel,Fanny Knöspel,Daniel Knobeloch,Andreas K. Nussler,Jörg C. Gerlach,Jörg C. Gerlach,Katrin Zeilinger +9 more
TL;DR: The results from this study indicate that HepaRG cells could provide a suitable alternative to pHH in pharmaceutical research and development for metabolism studies such as CYP induction or sub-chronic to chronic hepatotoxicity studies.
Journal ArticleDOI
State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology.
Natalie Alépée,Anthony Bahinski,Mardas Daneshian,Bart De Wever,Ellen Fritsche,Alan M. Goldberg,Jan Hansmann,Thomas Hartung,John W. Haycock,Helena T. Hogberg,Lisa Hoelting,Jens M. Kelm,Suzanne Kadereit,Emily A. McVey,Robert Landsiedel,Marcel Leist,Marc Lübberstedt,Fozia Noor,Christian Pellevoisin,Dirk Petersohn,Uwe Pfannenbecker,Kerstin Reisinger,Tzutzuy Ramirez,Barbara Rothen-Rutishauser,Monika Schäfer-Korting,Katrin Zeilinger,Marie Gabriele Zurich +26 more
TL;DR: This review summarizes the state of the art concerning commonalities of the different models and indicates a roadmap for the successful implementation of 3D models in routine screening.
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Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.
Katrin Zeilinger,Thomas Schreiter,Malin Darnell,Therese Söderdahl,Marc Lübberstedt,Birgitta Dillner,Daniel Knobeloch,Andreas K. Nussler,Jörg C. Gerlach,Tommy B. Andersson +9 more
TL;DR: The down-scaled multicompartment hollow fiber technology allows stable maintenance of primary human liver cells and provides an innovative tool for pharmacological and kinetic studies of hepatic functions with small cell numbers.
Journal ArticleDOI
Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies
Stefan A. Hoffmann,Ursula Müller-Vieira,Klaus M. Biemel,Daniel Knobeloch,Sandra Heydel,Marc Lübberstedt,Andreas K. Nussler,Tommy B. Andersson,Jörg C. Gerlach,Katrin Zeilinger +9 more
TL;DR: Diclofenac metabolism, CYP activities and gene expression levels were considerably more stable inBioreactor cultures, making the novel bioreactor a useful tool for pharmacological or toxicological investigations requiring a highly physiological in vitro representation of the liver.
Journal ArticleDOI
Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology
Jia Dong,Carl-Fredrik Mandenius,Marc Lübberstedt,Thomas Urbaniak,Andreas K. Nussler,Daniel Knobeloch,Jörg C. Gerlach,Jörg C. Gerlach,Katrin Zeilinger +8 more
TL;DR: Optimization of cell culture media based on statistical experimental design methodology is a widely used approach for improving cultivation conditions and it was possible to conclude that hepatocyte growth factor, epidermal growth factors, and oncostatin M had decisive effects on the metabolic functions of primary human hepatocytes.