M
Marcel Wiesweg
Researcher at University of Duisburg-Essen
Publications - 64
Citations - 1247
Marcel Wiesweg is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 34 publications receiving 580 citations.
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Journal ArticleDOI
Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry
Julien Mazieres,Alexander Drilon,Amélie Lusque,Laurent Mhanna,Alexis B. Cortot,Laura Mezquita,A. Thai,C. Mascaux,Sébastien Couraud,Remi Veillon,M. van den Heuvel,Joel W. Neal,Nir Peled,Martin Früh,Terry L. Ng,Valérie Gounant,Sanjay Popat,Joachim Diebold,Joshua K. Sabari,Viola W. Zhu,Sacha I. Rothschild,Paolo Bironzo,Alex Martinez-Marti,Alessandra Curioni-Fontecedro,Rafael Rosell,Mickaël Lattuca-Truc,Marcel Wiesweg,Benjamin Besse,Benjamin Solomon,Fabrice Barlesi,R.D. Schouten,Heather A. Wakelee,D.R. Camidge,Gérard Zalcman,Silvia Novello,S-H.I. Ou,Julie Milia,Oliver Gautschi +37 more
TL;DR: In certain subgroups, PFS was positively associated with PD-L1 expression (KRAS, EGFR) and with smoking status (BRAF, HER2) and the lack of response in the ALK group was notable.
Journal ArticleDOI
High Prevalence of Concomitant Oncogene Mutations in Prospectively Identified Patients with ROS1-Positive Metastatic Lung Cancer
Marcel Wiesweg,Wilfried Eberhardt,Henning Reis,Saskia Ting,Nikoleta Savvidou,Charlotte Skiba,Thomas Herold,Daniel C. Christoph,Johannes Meiler,Karl Worm,Stefan Kasper,Dirk Theegarten,Jörg Hense,Thomas Hager,Kaid Darwiche,Filiz Oezkan,Clemens Aigner,Stefan Welter,Hilmar Kühl,Martin Stuschke,Kurt Werner Schmid,Martin Schuler +21 more
TL;DR: Heterogeneity in ROS1‐positive metastatic lung adenocarcinomas frequently harbor concomitant oncogenic driver mutations, which provides additional therapeutic options if discovered by multiplex biomarker testing and repeat biopsies.
Journal ArticleDOI
MET Expression in Advanced Non-Small-Cell Lung Cancer: Effect on Clinical Outcomes of Chemotherapy, Targeted Therapy, and Immunotherapy.
Henning Reis,Martin Metzenmacher,Moritz Goetz,Nikoleta Savvidou,Kaid Darwiche,Clemens Aigner,Thomas Herold,Wilfried Eberhardt,Charlotte Skiba,Jörg Hense,Isabel Virchow,Daniela Westerwick,Simon Bogner,Saskia Ting,Stefan Kasper,Martin Stuschke,Felix Nensa,Ken Herrmann,Thomas Hager,Kurt Werner Schmid,Martin Schuler,Marcel Wiesweg +21 more
TL;DR: In this article, the effect of MET expression and MET genomic aberrations on the outcome of patients with advanced or metastatic pulmonary adenocarcinomas prospectively enrolled in an institutional precision oncology program was investigated.
Journal ArticleDOI
Pathogenic and targetable genetic alterations in 70 urachal adenocarcinomas.
Henning Reis,Kristan E. van der Vos,Christian Niedworok,Thomas Herold,Orsolya Módos,Attila Szendrői,Thomas Hager,Marc Ingenwerth,Daniel J. Vis,Mark A. Behrendt,Jeroen de Jong,Michiel S. van der Heijden,Benoit Peyronnet,Romain Mathieu,Marcel Wiesweg,Jason Ablat,Krzysztof Okoń,Yuri Tolkach,Dávid Keresztes,Nikolett Nagy,Felix Bremmer,Nadine T. Gaisa,Piotr Chlosta,Joerg Kriegsmann,Ilona Kovalszky,József Tímár,Glen Kristiansen,Heinz-Joachim Radzun,Ruth Knüchel,Martin Schuler,Peter C. Black,Herbert Rübben,Boris Hadaschik,Kurt Werner Schmid,Bas W.G. van Rhijn,Péter Nyirády,Tibor Szarvas +36 more
TL;DR: The molecular profile strengthens the notion that UrC is a distinct entity on the genomic level with closer resemblance to colorectal than to bladder cancer, with potential implications for anti‐EGFR therapy.
Journal ArticleDOI
Treatment outcome of atypical EGFR mutations in the German National Network Genomic Medicine Lung Cancer (nNGM).
Melanie Janning,Juliane Süptitz,Corinna Albers-Leischner,P Delpy,Amanda Tufman,Janna-Lisa Velthaus-Rusik,Martin Reck,Alex Jung,Diego Kauffmann-Guerrero,Irina Bonzheim,Stephanie Brändlein,Horst Hummel,Marcel Wiesweg,H. U. Schildhaus,Jan Stratmann,Moises Sebastian,Juergen Alt,Jessie E. Buth,I. Esposito,J. Berger,Lars Tögel,Felix C Saalfeld,Martin Wermke,Sabine Merkelbach-Bruse,Axel M. Hillmer,Frederick Klauschen,Carsten Bokemeyer,Reinhard Buettner,Jonathan Wolf,Sonja Loges +29 more
TL;DR: In this paper , a multicenter study of the national Network Genomic Medicine (nNGM) in Germany, 856 NSCLC cases with atypical EGFR mutations including co-occurring mutations were reported from 12 centers.