Marcelo D. Gomes

TL;DR: It is suggested that atrogin-1 specifically targets truncated M7t-cMyBP-C, but not WT-c myosin heavy chains, for proteasomal degradation and that MuRF1 indirectly reduces cMy BP-C levels by regulating the transcription of MHC.

TL;DR: A systematic analysis of the peptide sequences and lengths of several homologues of bioactive peptides and of a number of quenched-fluorescence (qf) opioid- and bradykinin-related peptides revealed that a minimum substrate length of six amino acids is required and that among the oligopeptides six to thirteen amino acid residues long, their susceptibility as substrates is highly variable.

TL;DR: Increased muscle wasting, lipid hydroperoxide, and superoxide dismutase, and decreased glutathione levels and total radical antioxidant capacity, were found on D5 in accordance with increased mRNA atrogin‐1 expression.

TL;DR: It is shown that perineal muscle LA is a suitable in vivo model to evaluate regulation of muscle proteolysis, closely resembling human muscle responsiveness to androgens, and that inhibition of ubiquitin-proteasome catabolic system is critical for trophic action of androgens in skeletal muscle.

TL;DR: The identification of FbxA is a novel protein containing a functional F-box domain that binds to Skp1 from the SCF-type ligase that provides another layer of complexity to xylanase induction and CCR phenomena in filamentous fungi.