M
Marco De Cecco
Researcher at Ariel University
Publications - 1
Citations - 243
Marco De Cecco is an academic researcher from Ariel University. The author has contributed to research in topics: DNA damage & Knockout mouse. The author has an hindex of 1, co-authored 1 publications receiving 117 citations.
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LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
Matthew Simon,Michael Van Meter,Julia Ablaeva,Zhonghe Ke,Raul S. Gonzalez,Taketo Taguchi,Marco De Cecco,Katerina I. Leonova,Valeria Kogan,Stephen L. Helfand,Nicola Neretti,Asael Roichman,Haim Y. Cohen,Margarita Meer,Vadim N. Gladyshev,Marina P. Antoch,Andrei V. Gudkov,John M. Sedivy,Andrei Seluanov,Vera Gorbunova +19 more
TL;DR: It is reported that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong type I interferon response via activation of cGAS, and modulating L1 activity may be an important strategy for attenuating age-related pathologies.