Stephen L. Helfand

TL;DR: It is shown that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity, indicating that STacs slow metazoan ageing by mechanisms that may be related to caloric restriction.

TL;DR: It is demonstrated that an increase in Drosophila Sir2 (dSir2) extends life span, whereas a decrease in dSir2 blocks the life-span-extending effect of calorie reduction or rpd3 mutations, which leads to a genetic pathway by which calorie restriction extends life spans and provides a framework for genetic and pharmacological studies of life span extension in metazoans.

TL;DR: It is proposed that the activation of retrotransposons is an important component of sterile inflammation that is a hallmark of ageing, and that L1 reverse transcriptase is a relevant target for the treatment of age-associated disorders.

TL;DR: This paper found that five independent P-element insertional mutations in a single gene resulted in a near doubling of the average adult life-span without a decline in fertility or physical activity.

TL;DR: It is shown that a mouse monoclonal antibody, HNK-1, which is directed against human natural killer cells also recognizes an antigenic determinant of human central and peripheral nervous system white matter by immunoperoxidase staining of tissue sections.