M
Margarita Meer
Researcher at Brigham and Women's Hospital
Publications - 21
Citations - 1406
Margarita Meer is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 8, co-authored 17 publications receiving 738 citations. Previous affiliations of Margarita Meer include Yale University & Barcelona Biomedical Research Park.
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Journal ArticleDOI
Local fitness landscape of the green fluorescent protein.
Karen S. Sarkisyan,Dmitry A. Bolotin,Margarita Meer,Dinara R. Usmanova,Dinara R. Usmanova,Alexander S. Mishin,George V. Sharonov,Dmitry N. Ivankov,Dmitry N. Ivankov,Nina G. Bozhanova,Mikhail S. Baranov,Onuralp Soylemez,Natalya S. Bogatyreva,Natalya S. Bogatyreva,Peter K. Vlasov,Evgeny S. Egorov,Maria D. Logacheva,Maria D. Logacheva,Maria D. Logacheva,Alexey S. Kondrashov,Alexey S. Kondrashov,Dmitry M. Chudakov,Ekaterina V. Putintseva,Ilgar Z. Mamedov,Dan S. Tawfik,Konstantin A. Lukyanov,Fyodor A. Kondrashov,Fyodor A. Kondrashov +27 more
TL;DR: An extensive region of the local fitness landscape of the green fluorescent protein from Aequorea victoria (avGFP) is visualize by measuring the native function (fluorescence) of tens of thousands of derivative genotypes of avGFP, indicating congruence between the fitness landscape properties at the local and global scales.
Journal ArticleDOI
Reprogramming to recover youthful epigenetic information and restore vision.
Yuancheng Lu,Benedikt Brommer,Benedikt Brommer,Xiao Tian,Anitha Krishnan,Margarita Meer,Margarita Meer,Chen Wang,Chen Wang,Daniel L. Vera,Qiurui Zeng,Yu D,Michael Bonkowski,Jae-Hyun Yang,Songlin Zhou,Songlin Zhou,Emma Hoffmann,Margarete M. Karg,Michael B. Schultz,Alice E. Kane,Noah Davidsohn,Ekaterina Korobkina,Karolina Chwalek,Luis A. Rajman,George M. Church,Konrad Hochedlinger,Vadim N. Gladyshev,Steve Horvath,Morgan E. Levine,Meredith S Gregory-Ksander,Bruce R. Ksander,Zhigang He,Zhigang He,David A. Sinclair,David A. Sinclair +34 more
TL;DR: Using the eye as a model CNS tissue, ectopic expression of Oct4, Sox2 and Klf4 genes (OSK) in mouse retinal ganglion cells restores youthful DNA methylation patterns and transcriptomes, promotes axon regeneration after injury, and reverses vision loss in a mouse model of glaucoma and in aged mice.
Journal ArticleDOI
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
Matthew Simon,Michael Van Meter,Julia Ablaeva,Zhonghe Ke,Raul S. Gonzalez,Taketo Taguchi,Marco De Cecco,Katerina I. Leonova,Valeria Kogan,Stephen L. Helfand,Nicola Neretti,Asael Roichman,Haim Y. Cohen,Margarita Meer,Vadim N. Gladyshev,Marina P. Antoch,Andrei V. Gudkov,John M. Sedivy,Andrei Seluanov,Vera Gorbunova +19 more
TL;DR: It is reported that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong type I interferon response via activation of cGAS, and modulating L1 activity may be an important strategy for attenuating age-related pathologies.
Journal ArticleDOI
A whole lifespan mouse multi-tissue DNA methylation clock.
Margarita Meer,Dmitriy I. Podolskiy,Alexander Tyshkovskiy,Alexander Tyshkovskiy,Vadim N. Gladyshev +4 more
TL;DR: A robust multi-tissue age predictor based on 435 CpG sites, which covers the entire mouse lifespan and remains unbiased with respect to any particular age group is constructed.
Journal ArticleDOI
Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness
TL;DR: It is estimated that a typical Watson–Crick switch involves crossing a fitness valley of a depth of about 10-3 or even about10-2, with AC intermediates being slightly more deleterious than GU intermediates, and compensatory evolution must proceed through rare intermediate variants that never reach fixation.