LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
Matthew Simon,Michael Van Meter,Julia Ablaeva,Zhonghe Ke,Raul S. Gonzalez,Taketo Taguchi,Marco De Cecco,Katerina I. Leonova,Valeria Kogan,Stephen L. Helfand,Nicola Neretti,Asael Roichman,Haim Y. Cohen,Margarita Meer,Vadim N. Gladyshev,Marina P. Antoch,Andrei V. Gudkov,John M. Sedivy,Andrei Seluanov,Vera Gorbunova +19 more
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TLDR
It is reported that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong type I interferon response via activation of cGAS, and modulating L1 activity may be an important strategy for attenuating age-related pathologies.About:
This article is published in Cell Metabolism.The article was published on 2019-04-02 and is currently open access. It has received 243 citations till now. The article focuses on the topics: Wild type & Interferon.read more
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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
TL;DR: The mechanisms and modulators of cellularsenescence establishment and induction of a senescence-associated secretory phenotype are discussed, and the potential of senolytic and senomorphic therapies in ageing and associated diseases is provided.
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The cGAS-STING pathway as a therapeutic target in inflammatory diseases.
TL;DR: The cGAS-STING pathway has emerged as a key mediator of inflammation in the settings of infection, cellular stress and tissue damage as discussed by the authors, which has enabled the development of selective small-molecule inhibitors with the potential to target the CGS-STing axis in a number of inflammatory diseases.
Journal ArticleDOI
The ageing epigenome and its rejuvenation.
TL;DR: The epigenetic changes that occur during ageing and the rapidly increasing knowledge of how these epigenetic mechanisms have an effect on healthspan and lifespan extension are discussed, and questions to guide future research on interventions to rejuvenate the epigenome and delay ageing processes are outlined.
Journal ArticleDOI
Hallmarks of aging: An expanding universe
TL;DR: In this paper , the authors proposed the following hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis.
Journal ArticleDOI
The quest to slow ageing through drug discovery
TL;DR: The most promising interventions to slow ageing are examined and group them into two tiers based on the robustness of the preclinical, and some clinical, results, in which the top tier includes rapamycin, senolytics, metformin, acarbose, spermidine, NAD + enhancers and lithium.
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Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Raul Mostoslavsky,Katrin F. Chua,Katrin F. Chua,David B. Lombard,Wendy W. Pang,Miriam R. Fischer,Lionel Gellon,Pingfang Liu,Gustavo Mostoslavsky,Sonia Franco,Michael M. Murphy,Kevin D. Mills,Parin Patel,Joyce T. Hsu,Andrew L. Hong,Ethan Ford,Hwei Ling Cheng,Caitlin Kennedy,Nomeli P. Nunez,Nomeli P. Nunez,Roderick T. Bronson,David Frendewey,Wojtek Auerbach,David M. Valenzuela,Margaret Karow,Michael O. Hottiger,Stephen D. Hursting,J. Carl Barrett,J. Carl Barrett,Leonard Guarente,Richard C. Mulligan,Bruce Demple,George D. Yancopoulos,Frederick W. Alt +33 more
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