M
Marco G. Casteleijn
Researcher at University of Helsinki
Publications - 24
Citations - 922
Marco G. Casteleijn is an academic researcher from University of Helsinki. The author has contributed to research in topics: Protein engineering & TIM barrel. The author has an hindex of 11, co-authored 23 publications receiving 725 citations. Previous affiliations of Marco G. Casteleijn include VTT Technical Research Centre of Finland & University of Oulu.
Papers
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Journal ArticleDOI
Pharmacokinetic aspects of retinal drug delivery.
Eva M. del Amo,Anna-Kaisa Rimpelä,Emma M. Heikkinen,Otto K. Kari,Eva Ramsay,Tatu Lajunen,Mechthild Schmitt,Laura Pelkonen,Madhushree Bhattacharya,Dominique Richardson,Astrid Subrizi,Tiina Turunen,Mika Reinisalo,Jaakko Itkonen,Elisa Toropainen,Marco G. Casteleijn,Heidi Kidron,Maxim Antopolsky,Kati-Sisko Vellonen,Marika Ruponen,Arto Urtti +20 more
TL;DR: This article aims to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment, based on the literature and unpublished data from the authors' laboratory.
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Enzyme controlled glucose auto-delivery for high cell density cultivations in microplates and shake flasks
Johanna Panula-Perälä,Juozas Siurkus,Antti Vasala,Robert Wilmanowski,Marco G. Casteleijn,Peter Neubauer,Peter Neubauer +6 more
TL;DR: The novel EnBase method is robust and simple-to-apply for high cell density cultivation in shake flasks and microwell plates and can easily be adapted to different microwell and deepwell plate formats and shake flask, which will be a helpful tool especially in high throughput applications.
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Application of aptamers in diagnostics, drug-delivery and imaging
TL;DR: Aptamers are small, single-stranded oligonucleotides (DNA or RNA) that bind to their target with high specificity and affinity that makes them superior over protein-based binding molecules in terms of labelling and conjugation strategies.
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Expression without boundaries: Cell-free protein synthesis in pharmaceutical research
TL;DR: Cell free expression can be used to modify protein solubility, stability, and pharmacokinetics of therapeutic proteins, potentially useful in protein development for biomaterial matrices, nanoparticles, and vaccines.
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Physicochemical studies on the stability of influenza haemagglutinin in vaccine bulk material
TL;DR: Fluorescence and circular dichroism spectroscopy are highly suitable techniques to monitor the stability of haemagglutinin in a straightforward and fast way.