Maxim Antopolsky

TL;DR: This article aims to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment, based on the literature and unpublished data from the authors' laboratory.

TL;DR: Evaluation of the roles of the barriers augments to design new drug delivery strategies for posterior segment of the eye suggested that choroidal blood flow removes most of the drug that has reached the choroid, but this requires experimental verification.

TL;DR: It is shown that the immunogenicity of OAds plays a key role in their efficacy and it can be exploited to direct the immune response system toward exogenous tumor epitopes, making PeptiCRAd a promising approach for clinical testing.

TL;DR: It is shown that Tat-related peptides enter cells on the basis of their cationic charge following different endocytosis pathways and that glycosaminoglycans on the cell surface negatively affect their uptake.

TL;DR: Thymoquinone was bound covalently to BSA, specifically on Cyst-34; WST-1 proliferation assay showed that BSA plays a protective role against TQ-induced cell death; pre-incubation with BSA prevented TQ from exerting its anti-proliferative effects against DLD-1 and HCT-116 human colon cancer cells.