Pharmacokinetic aspects of retinal drug delivery.
Eva M. del Amo,Anna-Kaisa Rimpelä,Emma M. Heikkinen,Otto K. Kari,Eva Ramsay,Tatu Lajunen,Mechthild Schmitt,Laura Pelkonen,Madhushree Bhattacharya,Dominique Richardson,Astrid Subrizi,Tiina Turunen,Mika Reinisalo,Jaakko Itkonen,Elisa Toropainen,Marco G. Casteleijn,Heidi Kidron,Maxim Antopolsky,Kati-Sisko Vellonen,Marika Ruponen,Arto Urtti +20 more
TLDR
This article aims to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment, based on the literature and unpublished data from the authors' laboratory.About:
This article is published in Progress in Retinal and Eye Research.The article was published on 2017-03-01 and is currently open access. It has received 407 citations till now. The article focuses on the topics: Drug delivery & Drug.read more
Citations
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Next generation antibody drugs: pursuit of the 'high-hanging fruit'.
Paul Carter,Greg A. Lazar +1 more
TL;DR: This Review focuses on emerging and novel mechanisms of action of antibodies and innovative targeting strategies that could extend their therapeutic applications, including antibody–drug conjugates, bispecific antibodies and antibody engineering to facilitate more effective delivery.
Journal ArticleDOI
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
Kai Kaarniranta,Hannu Uusitalo,Janusz Blasiak,Szabolcs Felszeghy,Ram Kannan,Anu Kauppinen,Antero Salminen,Debasish Sinha,Deborah A. Ferrington +8 more
TL;DR: The role of mitochondria in RPE degeneration and AMD pathology focused on mtDNA damage and repair, autophagy/mitophagy signaling, and regulation of inflammation is discussed.
Journal ArticleDOI
Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations.
Rubén Varela-Fernández,Victoria Díaz-Tomé,Andrea Luaces-Rodríguez,Andrea Conde-Penedo,Andrea Conde-Penedo,Xurxo García-Otero,Asteria Luzardo-Álvarez,Asteria Luzardo-Álvarez,Anxo Fernández-Ferreiro,Francisco J. Otero-Espinar,Francisco J. Otero-Espinar +10 more
TL;DR: An overview of pharmacokinetic and biopharmaceutics aspects for the most commonly-used ocular administration routes, including information of the absorption, distribution, and elimination, as well as the benefits and limitations of each one.
Journal Article
Intravenously Administrated Gold Nanoparticles Pass Through Blood-Retinal Barrier Depending on the Particle Size, and Induce No Retinal Toxicity
TL;DR: In this paper, intravenously administered gold nanoparticles were shown to pass through the blood-retinal barrier (BRB) and are distributed in all retinal layers without cytotoxicity.
Journal ArticleDOI
Principles of pharmacology in the eye.
Sahar Awwad,Sahar Awwad,Abeer Mohamed Ahmed,Abeer Mohamed Ahmed,Garima Sharma,Garima Sharma,Jacob S Heng,Peng T. Khaw,Steve Brocchini,Steve Brocchini,Alastair Lockwood +10 more
TL;DR: The least invasive routes for ocular drug administration are topical (e.g. eyedrops) and systemic formulations as discussed by the authors, however, topical drugs often display limited bioavailability due to many physical and biochemical barriers including the pre-corneal tear film, the structure and biophysiologic properties of the cornea, the limited volume that can be accommodated by the cul-desac, the lacrimal drainage system and reflex tearing.
References
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