O
Otto K. Kari
Researcher at University of Helsinki
Publications - 13
Citations - 814
Otto K. Kari is an academic researcher from University of Helsinki. The author has contributed to research in topics: Protein Corona & Surface plasmon resonance. The author has an hindex of 8, co-authored 13 publications receiving 491 citations.
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Journal ArticleDOI
Pharmacokinetic aspects of retinal drug delivery.
Eva M. del Amo,Anna-Kaisa Rimpelä,Emma M. Heikkinen,Otto K. Kari,Eva Ramsay,Tatu Lajunen,Mechthild Schmitt,Laura Pelkonen,Madhushree Bhattacharya,Dominique Richardson,Astrid Subrizi,Tiina Turunen,Mika Reinisalo,Jaakko Itkonen,Elisa Toropainen,Marco G. Casteleijn,Heidi Kidron,Maxim Antopolsky,Kati-Sisko Vellonen,Marika Ruponen,Arto Urtti +20 more
TL;DR: This article aims to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment, based on the literature and unpublished data from the authors' laboratory.
Journal ArticleDOI
The viral protein corona directs viral pathogenesis and amyloid aggregation
Kariem Ezzat,Kariem Ezzat,Maria Pernemalm,Sandra Pålsson,Thomas C. Roberts,Thomas C. Roberts,Peter Järver,Aleksandra Dondalska,Burcu Bestas,Michał J. Sobkowiak,Bettina Levänen,Magnus Sköld,Magnus Sköld,Elizabeth A. Thompson,Osama Saher,Osama Saher,Otto K. Kari,Tatu Lajunen,Eva Sverremark Ekström,Caroline Nilsson,Yevheniia Ishchenko,Tarja Malm,Matthew J.A. Wood,Ultan F. Power,Sergej Masich,Anders Lindén,Anders Lindén,Johan K. Sandberg,Janne Lehtiö,Anna-Lena Spetz,Samir El Andaloussi,Samir El Andaloussi +31 more
TL;DR: It is shown that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids, and that corona pre-coating differentially affects viral infectivity and immune cell activation.
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Artificially Cloaked Viral Nanovaccine for Cancer Immunotherapy
Manlio Fusciello,Flavia Fontana,Siri Tähtinen,Cristian Capasso,Sara Feola,Beatriz Martins,Jacopo Chiaro,Karita Peltonen,Leena Ylösmäki,Erkko Ylösmäki,Firas Hamdan,Otto K. Kari,Joseph Ndika,Harri Alenius,Harri Alenius,Arto Urtti,Arto Urtti,Jouni Hirvonen,Hélder A. Santos,Vincenzo Cerullo,Vincenzo Cerullo +20 more
TL;DR: ExtraCRAd, an oncolytic virus cloaked with tumour cell membrane, might serve as the next generation of personalized cancer vaccines with enhanced features over standard vaccination regimens, representing an alternative way to target cancer.
Journal ArticleDOI
Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation.
Otto K. Kari,Tatu Rojalin,Stefano Salmaso,Michela Barattin,Hanna Jarva,Seppo Meri,Marjo Yliperttula,Marjo Yliperttula,Tapani Viitala,Arto Urtti,Arto Urtti +10 more
TL;DR: The proof-of-concept for a multi-parametric surface plasmon resonance (MP-SPR) technique is demonstrated in monitoring the formation of a protein corona on surface-immobilized liposomes subjected to flowing 100 % human serum.
Journal ArticleDOI
In situ analysis of liposome hard and soft protein corona structure and composition in a single label-free workflow.
Otto K. Kari,Joseph Ndika,Petteri Parkkila,Antti Louna,Tatu Lajunen,Anne Puustinen,Tapani Viitala,Harri Alenius,Harri Alenius,Arto Urtti,Arto Urtti +10 more
TL;DR: The workflow addresses significant methodological gaps in biocorona research by providing truly complementary hard and soft corona compositions with corresponding in situ structural parameters for the first time.