M
Marco Igor Valencia-Sánchez
Researcher at New York University
Publications - 7
Citations - 196
Marco Igor Valencia-Sánchez is an academic researcher from New York University. The author has contributed to research in topics: Histone & Chromatin. The author has an hindex of 4, co-authored 4 publications receiving 97 citations.
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Journal ArticleDOI
Structural Basis of Dot1L Stimulation by Histone H2B Lysine 120 Ubiquitination
Marco Igor Valencia-Sánchez,Pablo De Ioannes,Miao Wang,Nikita Vasilyev,Nikita Vasilyev,Ruoyu Chen,Evgeny Nudler,Evgeny Nudler,Jean Paul Armache,Karim-Jean Armache +9 more
TL;DR: Cryo-EM structures of human Dot1L bound to H2BK120Ub and unmodified nucleosome substrates are reported, providing a strong foundation for understanding conserved crosstalk between histone modifications found at actively transcribed genes and offering a general model of how ubiquitin might regulate the activity of chromatin enzymes.
Journal ArticleDOI
Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation.
Marco Igor Valencia-Sánchez,Pablo De Ioannes,Miao Wang,David M. Truong,Rachel Lee,Jean Paul Armache,Jef D. Boeke,Karim-Jean Armache +7 more
TL;DR: In this article, it was shown that acetylation of histone H4 allosterically stimulates yeast Dot1 in a manner distinct from but coordinating with histone ubiquitination (H2BUb).
Journal ArticleDOI
Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.
Daniel Grau,Yixiao Zhang,Chul Hwan Lee,Chul Hwan Lee,Chul Hwan Lee,Marco Igor Valencia-Sánchez,Jenny Zhang,Miao Wang,Marlene Holder,Vladimir Svetlov,Vladimir Svetlov,Dongyan Tan,Evgeny Nudler,Evgeny Nudler,Danny Reinberg,Danny Reinberg,Thomas Walz,Karim-Jean Armache +17 more
TL;DR: In this paper, two cryo-EM structures of PRC2:EZH1, one as a monomer and another as a dimer bound to a nucleosome, were presented.
Journal ArticleDOI
The structure of a virus-encoded nucleosome
Marco Igor Valencia-Sánchez,Stephen Abini-Agbomson,Miao Wang,Rachel Lee,Nikita Vasilyev,Nikita Vasilyev,Jenny Zhang,Pablo De Ioannes,Bernard La Scola,Paul B. Talbert,Paul B. Talbert,Steve Henikoff,Steve Henikoff,Evgeny Nudler,Evgeny Nudler,Albert Erives,Karim-Jean Armache +16 more
TL;DR: The authors showed that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pair H2B-H2A and H4-H3.
Posted ContentDOI
A giant virus genome is densely packaged by stable nucleosomes within virions
Terri D. Bryson,Pablo De Ioannes,Marco Igor Valencia-Sánchez,Jorja G. Henikoff,Paul B. Talbert,Bernard La Scola,Karim-Jean Armache,Steven Henikoff +7 more
TL;DR: It is suggested that doublet histones have evolved for viral genome protection and may resemble an early stage of histone differentiation leading to the eukaryotic octameric nucleosome.