M
Marco L. Leung
Researcher at University of Texas MD Anderson Cancer Center
Publications - 17
Citations - 1956
Marco L. Leung is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Biology & Exome sequencing. The author has an hindex of 9, co-authored 11 publications receiving 1680 citations. Previous affiliations of Marco L. Leung include Children's Hospital of Philadelphia & University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Clonal evolution in breast cancer revealed by single nucleus genome sequencing
Yong Wang,Jill Waters,Marco L. Leung,Anna K. Unruh,Whijae Roh,Xiuqing Shi,Ken Chen,Paul Scheet,Selina Vattathil,Han Liang,Asha S. Multani,Hong Zhang,Rui Zhao,Franziska Michor,Funda Meric-Bernstam,Nicholas Navin +15 more
TL;DR: The data show that aneuploid rearrangements occurred early in tumour evolution and remained highly stable as the tumour masses clonally expanded, which has important implications for the diagnosis, therapeutic treatment and evolution of chemoresistance in breast cancer.
Journal ArticleDOI
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
Xiaohua Su,Deepavali Chakravarti,Min Soon Cho,Lingzhi Liu,Young Jin Gi,Yu Li Lin,Marco L. Leung,Adel K. El-Naggar,Chad J. Creighton,Milind Suraokar,Ignacio I. Wistuba,Elsa R. Flores +11 more
TL;DR: A novel understanding of the roles of TAp63 in tumour and metastasis suppression through the coordinate transcriptional regulation of Dicer and miR-130b is provided and may have implications for the many processes regulated by miRNAs.
Journal ArticleDOI
Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer.
Marco L. Leung,Alexander Davis,Ruli Gao,Anna Casasent,Yong Wang,Emi Sei,Eduardo Vilar,Dipen M. Maru,Scott Kopetz,Nicholas Navin +9 more
TL;DR: A highly multiplexed single-cell DNA sequencing approach was developed to trace the metastatic lineages of two CRC patients with matched liver metastases and revealed an unexpected independent tumor lineage that did not metastasize, and early progenitor clones with the "first hit" mutation in APC that subsequently gave rise to both the primary and metastatic tumors.
Journal ArticleDOI
SNES: single nucleus exome sequencing
TL;DR: A method is developed that combines flow-sorting of single G1/0 or G2/M nuclei, time-limited multiple-displacement-amplification, exome capture, and next-generation sequencing to generate high coverage data from single human cells, resulting in high detection efficiencies for single nucleotide variants and indels in single cells.
Journal ArticleDOI
Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8
Deepavali Chakravarti,Xiaohua Su,Min Soon Cho,Ngoc Hoang Bao Bui,Ngoc Hoang Bao Bui,Cristian Coarfa,Avinashnarayan Venkatanarayan,Avinashnarayan Venkatanarayan,Ashley Benham,Ramón E. Flores González,Ramón E. Flores González,Jennifer L. Alana,Weimin Xiao,Marco L. Leung,Marco L. Leung,Harina Vin,Harina Vin,Harina Vin,Io Long Chan,Arianexys Aquino,Arianexys Aquino,Nicole Müller,Nicole Müller,Hongran Wang,Austin J. Cooney,Jan Parker-Thornburg,Kenneth Y. Tsai,Kenneth Y. Tsai,Preethi H. Gunaratne,Elsa R. Flores,Elsa R. Flores +30 more
TL;DR: It is shown that loss of ΔNp63 leads to the generation of cells with self-renewing but limited differentiation capacity, and this regulation gives rise to a unique miRNA signature resulting in reprogramming cells to multipotency.