M
Marcus O. Muench
Researcher at University of California, San Francisco
Publications - 138
Citations - 7227
Marcus O. Muench is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 42, co-authored 134 publications receiving 6534 citations. Previous affiliations of Marcus O. Muench include Yonsei University & University of California.
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Journal ArticleDOI
Maternal Alloantigens Promote the Development of Tolerogenic Fetal Regulatory T Cells in Utero
Jeff E. Mold,Jakob Michaëlsson,Trevor D. Burt,Marcus O. Muench,Karen P. Beckerman,Michael P. Busch,Tzong-Hae Lee,Douglas F. Nixon,Joseph M. McCune +8 more
TL;DR: It is found that substantial numbers of maternal cells cross the placenta to reside in fetal lymph nodes, inducing the development of regulatory T cells (Tregs) that suppress fetal antimaternal immunity and persist at least until early adulthood.
Journal ArticleDOI
Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs
Charles H. Hannum,Janice Culpepper,D. Campbell,Terri McClanahan,Sandra Zurawski,Robert A. Kastelein,J. F. Bazan,S. Hudak,J. Wagner,Jeanine D. Mattson,J. Luh,G. Duda,N. Martina,D Peterson,S. Menon,A. Shanafelt,Marcus O. Muench,G. Kelner,Reiko Namikawa,D. Rennick,Maria Grazia Roncarolo,Albert Zlotnik,O. Rosnet,P. Dubreuil,Daniel Birnbaum,Frank Lee +25 more
TL;DR: The purified ligand enhances the response of mouse stem cells and a primitive human progenitor cell population to other growth factors such as interleukins IL-3 and IL-6 and to granulocyte-macrophage colony-stimulating factor, and also stimulates fetal thymocytes.
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Differential Downregulation of ACE2 by the Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63
Ilona Glowacka,Stephanie Bertram,Petra Herzog,Susanne Pfefferle,Imke Steffen,Imke Steffen,Imke Steffen,Marcus O. Muench,Graham Simmons,Heike Hofmann,Thomas Kuri,Friedemann Weber,Friedemann Weber,Friedemann Weber,Jutta Eichler,Christian Drosten,Stefan Pöhlmann +16 more
TL;DR: It was found that recombinant SARS-S bound to ACE2 and induced ACE2 shedding with higher efficiency than NL63-S and replicated efficiently in ACE2-positive Vero cells and reduced ACE2 expression, indicating robust receptor interference in the context of SARS but not NL63 infection.
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Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac
TL;DR: This study provides an effective approach to correct HBB mutations without leaving any genetic footprint in patient-derived iPSCs, thereby demonstrating a critical step toward the future application of stem cell-based gene therapy to monogenic diseases.
Journal ArticleDOI
Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection
Lin Ye,Jiaming Wang,Ashley I. Beyer,Fernando Teque,Thomas J. Cradick,Zhongxia Qi,Judy C. Chang,Gang Bao,Marcus O. Muench,Jingwei Yu,Jay A. Levy,Yuet Wai Kan +11 more
TL;DR: For the first time in induced pluripotent stem cells (iPSCs) the efficient and seamless derivation of a homozygous CCR5Δ32 mutation is reported, exactly mimicking the natural mutation, which may provide an approach toward a functional cure of HIV-1 infection.