M
Margarita Muiños-Gimeno
Researcher at Pompeu Fabra University
Publications - 5
Citations - 385
Margarita Muiños-Gimeno is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Gene silencing & microRNA. The author has an hindex of 5, co-authored 5 publications receiving 345 citations.
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Journal ArticleDOI
Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways
Margarita Muiños-Gimeno,Yolanda Espinosa-Parrilla,Yolanda Espinosa-Parrilla,Monica Guidi,Birgit Kagerbauer,Tessa Sipilä,Tessa Sipilä,Eduard Maron,Eduard Maron,Kristi Pettai,Laura Kananen,Ricard Navinés,Rocío Martín-Santos,Mònica Gratacòs,Andres Metspalu,Andres Metspalu,Iiris Hovatta,Iiris Hovatta,Xavier Estivill +18 more
TL;DR: This work is the first report of a possible implication of miRNAs in the etiology of panic disorder and Transcriptome analysis of neuroblastoma cells transfected with miR-22 and miR
Journal ArticleDOI
Overexpression of miR-128 specifically inhibits the truncated isoform of NTRK3 and upregulates BCL2 in SH-SY5Y neuroblastoma cells
Monica Guidi,Margarita Muiños-Gimeno,Birgit Kagerbauer,Eulàlia Martí,Xavier Estivill,Yolanda Espinosa-Parrilla +5 more
TL;DR: Results show that the regulation of NTRK3 by microRNAs is isoform-specific and suggest that neurotrophin-mediated processes are strongly linked to microRNA-dependent mechanisms, and open new perspectives for the study of the physiological role of miR-128 and its possible involvement in cell death/survival processes.
Journal ArticleDOI
Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders.
Margarita Muiños-Gimeno,Monica Guidi,Birgit Kagerbauer,Rocío Martín-Santos,Ricard Navinés,Pino Alonso,José M. Menchón,Mònica Gratacòs,Xavier Estivill,Yolanda Espinosa-Parrilla +9 more
TL;DR: Analysis of genetic variation in two different isoforms of NTRK3 as candidate susceptibility factors for anxiety by resequencing their 3′UTRs implicate miRNAs as key posttranscriptional regulators of NtrK3 and provide a framework for allele‐specific miRNA regulation of N TRK3 in anxiety disorders.
Journal ArticleDOI
Design and evaluation of a panel of single-nucleotide polymorphisms in microRNA genomic regions for association studies in human disease.
Margarita Muiños-Gimeno,Magda Montfort,Mònica Bayés,Xavier Estivill,Yolanda Espinosa-Parrilla,Yolanda Espinosa-Parrilla +5 more
TL;DR: A designed miRNA SNP panel could help to identify still hidden links between miRNAs and human disease and a comparison of the minor allele frequencies between Spanish and HapMap population samples confirmed the applicability of this SNP panel to the study of complex disorders among the Spanish population.
Book ChapterDOI
MicroRNA-Mediated Regulation and the Genetic Susceptibility to Anxiety Disorders
TL;DR: Increasing evidence at a population and experimental level indicates that genetic variation at regulatory regions underlies differences in gene expression and could be a major contributor to phenotypic diversity in human populations, particularly in the case of psychiatric disorders.