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Birgit Kagerbauer
Researcher at Pompeu Fabra University
Publications - 9
Citations - 1409
Birgit Kagerbauer is an academic researcher from Pompeu Fabra University. The author has contributed to research in topics: Gene silencing & microRNA. The author has an hindex of 9, co-authored 9 publications receiving 1256 citations.
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Journal ArticleDOI
MicroRNA profiling of Parkinson’s disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
Elena Miñones-Moyano,Sílvia Porta,Geòrgia Escaramís,Raquel Rabionet,Susana Iraola,Birgit Kagerbauer,Yolanda Espinosa-Parrilla,Isidre Ferrer,Isidre Ferrer,Xavier Estivill,Eulàlia Martí +10 more
TL;DR: It is proposed that early deregulation of miR-34b/c in PD triggers downstream transcriptome alterations underlying mitochondrial dysfunction and oxidative stress, which ultimately compromise cell viability.
Journal ArticleDOI
Evidence for the biogenesis of more than 1,000 novel human microRNAs
Marc R. Friedländer,Esther Lizano,Anna J.S. Houben,Daniela Bezdan,Mónica Bañez-Coronel,Grzegorz Kudla,Elisabet Mateu-Huertas,Birgit Kagerbauer,Justo González,Kevin Chen,Emily M LeProust,Eulàlia Martí,Xavier Estivill +12 more
TL;DR: Evidence is presented that the complement of human miRNA genes is substantially larger than anticipated, and that more are likely to be discovered in the future as more tissues and experimental conditions are sequenced to greater depth.
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Human microRNAs miR-22, miR-138-2, miR-148a, and miR-488 are associated with panic disorder and regulate several anxiety candidate genes and related pathways
Margarita Muiños-Gimeno,Yolanda Espinosa-Parrilla,Yolanda Espinosa-Parrilla,Monica Guidi,Birgit Kagerbauer,Tessa Sipilä,Tessa Sipilä,Eduard Maron,Eduard Maron,Kristi Pettai,Laura Kananen,Ricard Navinés,Rocío Martín-Santos,Mònica Gratacòs,Andres Metspalu,Andres Metspalu,Iiris Hovatta,Iiris Hovatta,Xavier Estivill +18 more
TL;DR: This work is the first report of a possible implication of miRNAs in the etiology of panic disorder and Transcriptome analysis of neuroblastoma cells transfected with miR-22 and miR
Journal ArticleDOI
A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity
Mónica Bañez-Coronel,Sílvia Porta,Sílvia Porta,Birgit Kagerbauer,Elisabet Mateu-Huertas,Lorena Pantano,Isidre Ferrer,Manuel Guzmán,Xavier Estivill,Eulàlia Martí +9 more
TL;DR: Evidence is provided to support that the mutant HTT CAG repeats interfere with cell viability at the RNA level, and a possible link between HD and sCAG expression with an aberrant activation of the siRNA/miRNA gene silencing machinery, which may trigger a detrimental response is suggested.
Journal ArticleDOI
Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia
Ester Saus,Virginia Soria,Geòrgia Escaramís,Francesca Vivarelli,José Manuel Crespo,José Manuel Crespo,Birgit Kagerbauer,José M. Menchón,José M. Menchón,Mikel Urretavizcaya,Mikel Urretavizcaya,Mònica Gratacòs,Xavier Estivill +12 more
TL;DR: Data indicate that abnormal processing of pre-miR-182 in patients carrying the T allele of the rs76481776 polymorphism may contribute to the dysregulation of circadian rhythms in MD patients with insomnia, which could influence expression levels of the mature form of miR- 182 and might increase downregulation in some of its target genes.