M
Maria A. Gandini
Researcher at Alberta Children's Hospital
Publications - 38
Citations - 573
Maria A. Gandini is an academic researcher from Alberta Children's Hospital. The author has contributed to research in topics: Voltage-dependent calcium channel & Calcium channel. The author has an hindex of 12, co-authored 35 publications receiving 397 citations. Previous affiliations of Maria A. Gandini include CINVESTAV & Instituto Politécnico Nacional.
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Journal ArticleDOI
Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons
Eduardo Javier López Soto,Francina Agosti,Agustina Cabral,Emilio Román Mustafá,Valentina Martínez Damonte,Maria A. Gandini,Silvia Susana Rodríguez,Daniel Castrogiovanni,Ricardo Felix,Mario Perello,Jesica Raingo +10 more
TL;DR: Constitutive and ligand-dependent GHSR1a activity attenuates CaV2 current and hypothalamic GABA release through distinct mechanisms and signaling pathways.
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RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors
TL;DR: A key function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect modulation of the channel, which is vitally important for the release of vesicles from the rod ribbon.
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Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels
Shreya S. Bellampalli,Yingshi Ji,Yingshi Ji,Aubin Moutal,Song Cai,E. M. Kithsiri Wijeratne,Maria A. Gandini,Jie Yu,Aude Chefdeville,Angie Dorame,Lindsey A. Chew,Cynthia L. Madura,Shizhen Luo,Gabriella Molnar,May Khanna,John M. Streicher,Gerald W. Zamponi,A. A. Leslie Gunatilaka,Rajesh Khanna +18 more
TL;DR: The broad-spectrum biological and medicinal properties reported, including anti-HIV and anticancer activities of BA and its derivatives, position this plant-derived small molecule natural product as a potential nonopioid therapy for management of chronic pain.
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Functional Coupling of Rab3-interacting Molecule 1 (RIM1) and L-type Ca2+ Channels in Insulin Release
Maria A. Gandini,Alejandro Sandoval,Ricardo González-Ramírez,Yasuo Mori,Michel De Waard,Ricardo Felix +5 more
TL;DR: A novel functional coupling between RIM1 and the L-type CaV channels via the CaVβ auxiliary subunit that contribute to determine insulin secretion is unveiled.
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Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk
Junting Huang,Maria A. Gandini,Lina Chen,Said M’Dahoma,Patrick L. Stemkowski,Hyunjae Chung,Daniel A. Muruve,Gerald W. Zamponi +7 more
TL;DR: It is reported that hyperactivity of innate immunity primes and initiates pain states via the TLR2-interleukin-33 (IL-33) axis, and blocking IL-33 receptors at the spinal level mediates analgesia during acute and chronic inflammatory pain, underscoring an important function of IL- 33 in pain signaling.