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Emilio Román Mustafá
Researcher at National University of La Plata
Publications - 17
Citations - 229
Emilio Román Mustafá is an academic researcher from National University of La Plata. The author has contributed to research in topics: Receptor & Medicine. The author has an hindex of 6, co-authored 10 publications receiving 133 citations. Previous affiliations of Emilio Román Mustafá include National Scientific and Technical Research Council.
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Journal ArticleDOI
Constitutive and ghrelin-dependent GHSR1a activation impairs CaV2.1 and CaV2.2 currents in hypothalamic neurons
Eduardo Javier López Soto,Francina Agosti,Agustina Cabral,Emilio Román Mustafá,Valentina Martínez Damonte,Maria A. Gandini,Silvia Susana Rodríguez,Daniel Castrogiovanni,Ricardo Felix,Mario Perello,Jesica Raingo +10 more
TL;DR: Constitutive and ligand-dependent GHSR1a activity attenuates CaV2 current and hypothalamic GABA release through distinct mechanisms and signaling pathways.
Journal ArticleDOI
Metabolic insights from a GHSR-A203E mutant mouse model.
Lola Torz,Sherri Osborne-Lawrence,Juan A. Rodriguez,Zhenyan He,María Paula Cornejo,Emilio Román Mustafá,Chunyu Jin,Natalia Petersen,Morten Hedegaard,Maja Nybo,Valentina Martínez Damonte,Nathan P. Metzger,Bharath K. Mani,Kevin W. Williams,Jesica Raingo,Mario Perello,Birgitte Holst,Jeffrey M. Zigman +17 more
TL;DR: Although the A203E mutation does not block ghrelin-evoked signaling as assessed using in vitro and ex vivo models, GHSR-A203E mice lack the usual acute food intake response to administered gh Relin in vivo, and that constitutive G HSR activity contributes to the native depolarizing conductance of GHSr-expressing arcuate NPY neurons.
Journal ArticleDOI
Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated Ca2+ channels in a CaVβ-dependent manner.
Emilio Román Mustafá,Eduardo Javier López Soto,Valentina Martínez Damonte,Silvia Susana Rodríguez,Diane Lipscombe,Jesica Raingo +5 more
TL;DR: A new mechanism that modulates the trafficking of several CaV channel subtypes to the plasma membrane through the constitutive activity of the exceptional G-protein-coupled receptor GHSR is shown.
Journal ArticleDOI
Development of a novel fluorescent ligand of growth hormone secretagogue receptor based on the N-Terminal Leap2 region.
Franco Barrile,Céline M'Kadmi,Pablo Nicolás de Francesco,Agustina Cabral,Guadalupe García Romero,Emilio Román Mustafá,Sonia Cantel,Marjorie Damian,Sophie Mary,Séverine Denoyelle,Jean Louis Banères,Jacky Marie,Jesica Raingo,Jean-Alain Fehrentz,Mario Perello +14 more
TL;DR: In mice, centrally-injected F-LEAP2 reduced ghrelin-induced food intake, in a similar fashion to LEAP2, and specifically labeled cells in GHSR-expressing brain areas, and represents a valuable tool to study the biology of G HSR in vitro and in vivo.
Journal ArticleDOI
The intriguing ligand-dependent and ligand-independent actions of the growth hormone secretagogue receptor on reward-related behaviors.
María Paula Cornejo,Emilio Román Mustafá,Franco Barrile,Daniela Cassano,Pablo Nicolás de Francesco,Jesica Raingo,Mario Perello +6 more
TL;DR: It is concluded that GHSR is a key regulator of the mesocorticolimbic pathway that influences its activity and, consequently, modulates reward-related behaviors via ligand-dependent and ligands-independent actions.